Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

doi:10.1038/ni.3002

Review

. 2014 Nov;15(11):1009-16.

doi: 10.1038/ni.3002.

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

Ying Wang¹, Xiaodong Chen¹, Wei Cao¹, Yufang Shi²

Affiliations

¹ Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² 1] Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2] Child Health Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. [3] Soochow Institutes for Translational Medicine, Soochow University, Suzhou, China.

PMID: 25329189
DOI: 10.1038/ni.3002

Review

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

Ying Wang et al. Nat Immunol. 2014 Nov.

. 2014 Nov;15(11):1009-16.

doi: 10.1038/ni.3002.

Authors

Ying Wang¹, Xiaodong Chen¹, Wei Cao¹, Yufang Shi²

Affiliations

¹ Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² 1] Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2] Child Health Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. [3] Soochow Institutes for Translational Medicine, Soochow University, Suzhou, China.

PMID: 25329189
DOI: 10.1038/ni.3002

Abstract

Mesenchymal stem cells (MSCs) are multipotent stromal cells that exist in many tissues and are capable of differentiating into several different cell types. Exogenously administered MSCs migrate to damaged tissue sites, where they participate in tissue repair. Their communication with the inflammatory microenvironment is an essential part of this process. In recent years, much has been learned about the cellular and molecular mechanisms of the interaction between MSCs and various participants in inflammation. Depending on their type and intensity, inflammatory stimuli confer on MSCs the ability to suppress the immune response in some cases or to enhance it in others. Here we review the current findings on the immunoregulatory plasticity of MSCs in disease pathogenesis and therapy.

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[1] Cell Biol Int. 2009 Jul;33(7):772-7 - PubMed

[2] Cell Biol Int. 2009 Jul;33(7):772-7 - PubMed

[3] Cell Death Differ. 2014 Mar;21(3):388-96 - PubMed

[4] Cell Death Differ. 2014 Mar;21(3):388-96 - PubMed

[5] Cancer Res. 2014 Mar 1;74(5):1576-87 - PubMed

[6] Cancer Res. 2014 Mar 1;74(5):1576-87 - PubMed

[7] Cell Stem Cell. 2012 May 4;10(5):544-55 - PubMed

[8] Cell Stem Cell. 2012 May 4;10(5):544-55 - PubMed

[9] Blood. 2008 Feb 1;111(3):1327-33 - PubMed

[10] Blood. 2008 Feb 1;111(3):1327-33 - PubMed

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Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

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Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

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