Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Nov;14(11):731-43.
doi: 10.1038/nri3755. Epub 2014 Oct 17.

25-Hydroxycholesterols in innate and adaptive immunity

Jason G Cyster  1 , Eric V Dang  2 , Andrea Reboldi  2 , Tangsheng Yi  3
Affiliations
Review

25-Hydroxycholesterols in innate and adaptive immunity

Jason G Cyster et al. Nat Rev Immunol. 2014 Nov.

Abstract

Cholesterol and components of the cholesterol biosynthetic pathway have fundamental roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as important regulators of immune function. This involves effects on the cholesterol biosynthetic pathway and cell membrane properties, which can have antiviral and anti-inflammatory influences. In addition, a dihydroxylated form of cholesterol functions as an immune cell guidance cue by engaging the G protein-coupled receptor EBI2, and it is required for mounting adaptive immune responses. In this Review, we summarize the current understanding of the closely related oxysterols 25-hydroxycholesterol and 7α,25-dihydroxycholesterol, and the growing evidence that they have wide-ranging influences on innate and adaptive immunity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Immunol. 2011 Sep 15;187(6):3026-32 - PubMed
    1. Cell Mol Life Sci. 2012 Oct;69(20):3395-418 - PubMed
    1. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14869-74 - PubMed
    1. Hum Mol Genet. 2012 Jun 15;21(12):2815-24 - PubMed
    1. Blood. 2008 Nov 1;112(9):3563-73 - PubMed

Publication types

Substances

LinkOut - more resources