Antibody B cell responses in HIV-1 infection
- PMID: 25240985
- DOI: 10.1016/j.it.2014.08.007
Antibody B cell responses in HIV-1 infection
Abstract
In rare cases, B cells can supply HIV-1-infected individuals with unconventional antibodies equipped to neutralize the wide diversity of viral variants. Innovations in single-cell cloning, high-throughput sequencing, and structural biology methods have enabled the capture and thorough characterization of these exceptionally potent broadly neutralizing antibodies (bNAbs). Here, I review the recent findings in humoral responses to HIV-1, focusing on the interplay between naturally occurring bNAbs and the virus both at systemic and mucosal levels. In this context, I discuss how an improved understanding of bNAb generation may provide invaluable insight into the fundamental mechanisms governing adaptive B cell responses to viruses, and how this knowledge is currently contributing to the development of vaccine and therapeutic strategies against HIV-1.
Keywords: B cells; HIV-1; adaptive immunity; antibodies; viruses.
Copyright © 2014 Elsevier Ltd. All rights reserved.
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