Skip to main page content
U.S. flag

An official website of the United States government

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Sep 15:14:672.
doi: 10.1186/1471-2407-14-672.

Contrast enhanced computed tomography is indicative for angiogenesis pattern and display prognostic significance in breast cancer

Jianyi Li, Yang Zhang, Wenhai Zhang  1 , Yang Gao, Shi Jia, Jiao Guo
Affiliations

Contrast enhanced computed tomography is indicative for angiogenesis pattern and display prognostic significance in breast cancer

Jianyi Li et al. BMC Cancer. .

Abstract

Background: The Prognostic value of microvessel density in cancer remains unclear. Recent studies have suggested that the uneven distribution of microvessels in tumours caused the variation in sample selection which led to different prognostic outcome. The enhancement pattern of Contrast-enhanced computed tomography (CECT) is determined in part by the microvessel distribution in solid tumors. Therefore, survival analysis of tumors grouping by the enhancement pattern and the pattern of microvessel distribution is important.

Methods: Survival analysis grouped by the tumor enhancement pattern and the microvessel distribution was carried out in 255 patients with invasive ductal carcinoma.

Results: There were significant differences in overall survival (OS) and disease-free survival (DFS) among the homogeneous, heterogeneous and peripheral enhancement groups. There were significant differences between OS and DFS groups with uniform and uneven distributions of microvessels.

Conclusions: The distribution of microvessels in a tumor is a potential prognostic indicator in patients with breast cancer, and can be assessed by CECT prior the operation.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of microvessels. A. CECT images. B. Immunohistochemical images.
Figure 2
Figure 2
Diagram of tumor partition. Illustration: It was the main aim to lay the chest flat so that the edge of tumor must be located between the tumor and the normal breast tissue.
Figure 3
Figure 3
The survival analysis and cox proportional hazards model. A. Analysis grouping by the Clinicopathological Subtypes. B. Cox proportional hazards model and Analysis grouping by the Patterns of Tumor Enhancement. Cox proportional hazards model of biological factors (including tumor enhancement mode under CT). C. Cox proportional hazards model and Analysis grouping by the Distribution of MVD. Cox proportional hazards model of biological factors (including difference of MVD).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bikfalvi A. Angiogenesis and invasion in cancer. Handb Clin Neurol. 2012;104:35–43. doi: 10.1016/B978-0-444-52138-5.00003-7. - DOI - PubMed
    1. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini G. Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst. 1992;84(24):1875–1887. doi: 10.1093/jnci/84.24.1875. - DOI - PubMed
    1. Weidner N, Carroll PR, Flax J, Blumenfeld W, Folkman J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol. 1993;143(2):401–409. - PMC - PubMed
    1. Nadkarni NJ, Geest KD, Neff T, Young BD, Bender DP, Ahmed A, Smith BJ, Button A, Goodheart MJ. Cancer Lett. 2012. Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer. - PubMed
    1. Tretiakova M, Antic T, Binder D, Kocherginsky M, Liao C, Taxy JB, Oto A. Hum Pathol. 2012. Microvessel density is not increased in prostate cancer: digital imaging of routine sections and tissue microarrays. - PubMed
Pre-publication history
    1. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/14/672/prepub

Publication types

MeSH terms

Substances