RNA Function. RNA and dynamic nuclear organization

doi:10.1126/science.1252966

. 2014 Sep 12;345(6202):1240-1.

doi: 10.1126/science.1252966.

RNA Function. RNA and dynamic nuclear organization

John Rinn¹, Mitchell Guttman²

Affiliations

¹ Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA. johnrinn@fas.harvard.edu mguttman@caltech.edu.
² Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. johnrinn@fas.harvard.edu mguttman@caltech.edu.

PMID: 25214588
PMCID: PMC4186717
DOI: 10.1126/science.1252966

RNA Function. RNA and dynamic nuclear organization

John Rinn et al. Science. 2014.

. 2014 Sep 12;345(6202):1240-1.

doi: 10.1126/science.1252966.

Authors

John Rinn¹, Mitchell Guttman²

Affiliations

¹ Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA. johnrinn@fas.harvard.edu mguttman@caltech.edu.
² Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. johnrinn@fas.harvard.edu mguttman@caltech.edu.

PMID: 25214588
PMCID: PMC4186717
DOI: 10.1126/science.1252966

No abstract available

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Figures

**Figure 1. An RNA roadmap to nuclear organization**
Cutaway of the nucleus highlighting three organizational levels: active (left) and inactive (bottom) regions, and nuclear bodies (right). Clockwise from right to left: The nucleolus is formed around actively transcribed rRNA sites; paraspeckles are formed by the Neat1 lncRNA; the Malat1 lncRNA is present within the nuclear speckle, and actively transcribed genes are repositioned close to nuclear speckles; the inactive X chromosome (Barr body) is coated by the Xist lncRNA and dynamically repositioned from the active to inactive compartments where it is localized to the periphery of the nucleus; lncRNAs can mediate gene-gene interactions across chromosomes (bottom panel inset) and within chromosomes (top panel inset).

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[1] Nickerson JA, Krochmalnic G, Wan KM, Penman S. Proc Natl Acad Sci USA. 1989;86:177. - PMC - PubMed

[2] Nickerson JA, Krochmalnic G, Wan KM, Penman S. Proc Natl Acad Sci USA. 1989;86:177. - PMC - PubMed

[3] Misteli T. Cell. 2007;128:787. - PubMed

[4] Misteli T. Cell. 2007;128:787. - PubMed

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RNA Function. RNA and dynamic nuclear organization

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RNA Function. RNA and dynamic nuclear organization

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