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. 2014 Sep 5:5:4821.
doi: 10.1038/ncomms5821.

Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure

Milas Ugur  1 , Olga Schulz  1 , Manoj B Menon  2 , Andreas Krueger  1 , Oliver Pabst  3
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Free article

Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure

Milas Ugur et al. Nat Commun. .
Free article

Abstract

Effector and memory CD4(+) T cells acquire distinct migratory properties depending on the type and location of the immune responses. Due to the highly dynamic nature of T cell circulation, the comprehensive analysis of these migratory routes requires dedicated experimental approaches. Here, we analyse the migration of effector/memory CD4(+) T cells by long-term in vivo cell tracking. We identify a resident population of antigen-experienced CD4(+) T cells that resides in lymph nodes and Peyer's patches without circulation or proliferation. Resident CD4(+) T cells constitute up to 50% of all effector/memory cells, including, but not limited to, follicular helper T cells. Furthermore, these non-circulating T cells possess a distinct T cell receptor repertoire and accumulate in Peyer's patches after continuous oral antigen exposure. Our results provide the first direct evidence for a resident population of effector/memory CD4(+) T cells that is retained in lymphoid tissues.

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