Impact of interferon-γ on hematopoiesis
- PMID: 25185711
- DOI: 10.1182/blood-2014-04-568451
Impact of interferon-γ on hematopoiesis
Abstract
The proinflammatory cytokine interferon-γ (IFN-γ) is well known for its important role in innate and adaptive immunity against intracellular infections and for tumor control. Yet, it has become clear that IFN-γ also has a strong impact on bone marrow (BM) output during inflammation, as it affects the differentiation of most hematopoietic progenitor cells. Here, we review the impact of IFN-γ on hematopoiesis, including the function of hematopoietic stem cells (HSCs) and more downstream progenitors. We discuss which hematopoietic lineages are functionally modulated by IFN-γ and through which underlying molecular mechanism(s). We propose the novel concept that IFN-γ acts through upregulation of suppressor of cytokine signaling molecules, which impairs signaling of several cytokine receptors. IFN-γ has also gained clinical interest from different angles, and we discuss how chronic IFN-γ production can lead to the development of anemia and BM failure and how it is involved in malignant hematopoiesis. Overall, this review illustrates the wide-ranging effect of IFN-γ on the (patho-)physiological processes in the BM.
© 2014 by The American Society of Hematology.
Similar articles
-
Interferon gamma inhibits the differentiation of mouse adult liver and bone marrow hematopoietic stem cells by inhibiting the activation of notch signaling.Stem Cell Res Ther. 2019 Jul 16;10(1):210. doi: 10.1186/s13287-019-1311-0. Stem Cell Res Ther. 2019. PMID: 31311586 Free PMC article.
-
The Regulatory Role of IFN-γ on the Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.Stem Cell Rev Rep. 2017 Dec;13(6):705-712. doi: 10.1007/s12015-017-9761-1. Stem Cell Rev Rep. 2017. PMID: 28852997 Review.
-
Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow.Eur J Immunol. 2016 Nov;46(11):2587-2596. doi: 10.1002/eji.201646326. Epub 2016 Sep 26. Eur J Immunol. 2016. PMID: 27594558
-
Parallels between immune driven-hematopoiesis and T cell activation: 3 signals that relay inflammatory stress to the bone marrow.Exp Cell Res. 2014 Dec 10;329(2):239-47. doi: 10.1016/j.yexcr.2014.09.016. Epub 2014 Sep 22. Exp Cell Res. 2014. PMID: 25246130 Review.
-
Interferon-γ impairs proliferation of hematopoietic stem cells in mice.Blood. 2013 May 2;121(18):3578-85. doi: 10.1182/blood-2012-05-432906. Epub 2013 Mar 13. Blood. 2013. PMID: 23487025
Cited by
-
Aplastic Anemia in the light of the COVID-19 pandemic: infection, vaccination, and pathophysiologic mechanisms.Ann Hematol. 2024 Dec;103(12):4989-5005. doi: 10.1007/s00277-024-06052-9. Epub 2024 Oct 23. Ann Hematol. 2024. PMID: 39441353 Review.
-
Concise Review: Modulating Cancer Immunity with Hematopoietic Stem and Progenitor Cells.Stem Cells. 2019 Feb;37(2):166-175. doi: 10.1002/stem.2933. Epub 2018 Nov 12. Stem Cells. 2019. PMID: 30353618 Free PMC article. Review.
-
Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease.Am J Pathol. 2023 Dec;193(12):2031-2046. doi: 10.1016/j.ajpath.2023.08.010. Epub 2023 Sep 7. Am J Pathol. 2023. PMID: 37689386 Free PMC article.
-
Dysfunction of CD169+ macrophages and blockage of erythrocyte maturation as a mechanism of anemia in Plasmodium yoelii infection.Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2311557120. doi: 10.1073/pnas.2311557120. Epub 2023 Sep 25. Proc Natl Acad Sci U S A. 2023. PMID: 37748059 Free PMC article.
-
Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4.Nat Commun. 2018 Feb 16;9(1):708. doi: 10.1038/s41467-018-03145-8. Nat Commun. 2018. PMID: 29453396 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
