Network pharmacology: a Rosetta Stone for traditional Chinese medicine
- PMID: 25160070
- DOI: 10.1002/ddr.21214
Network pharmacology: a Rosetta Stone for traditional Chinese medicine
Abstract
Network pharmacology, based on the theory of systems biology, is a new discipline that analyzes the biological network and screens out the nodes of particular interest, with the aim of designing poly-target drug molecule. It emphasizes maximizing drug efficacy and minimizing adverse effect via the multiple regulation of the signaling pathway. Coincidentally, almost all traditional Chinese medicine (TCM) and worldwide ethnomedicine exert therapeutic effect by targeting multiple molecules of the human body. In this overview, we offer a critique on the present perception of TCM and network pharmacology; illustrate the utility of network pharmacology in the study of single herb, medicine pair, and TCM formula; and summarize the recent progress of TCM-based drug discovery inspired by network pharmacology. Network pharmacology could be of great help in decreasing drug attrition rate and thus is essential in rational and cost-effective drug development. We also pinpoint the current TCM issues that could be tackled by the flexible combined use of network pharmacology and relevant disciplines.
Keywords: drug discovery; network pharmacology; traditional Chinese medicine (TCM).
© 2014 Wiley Periodicals, Inc.
Similar articles
-
Traditional Chinese medicine network pharmacology: theory, methodology and application.Chin J Nat Med. 2013 Mar;11(2):110-20. doi: 10.1016/S1875-5364(13)60037-0. Chin J Nat Med. 2013. PMID: 23787177 Review.
-
[Network pharmacology: new opportunity for the modernization of traditional Chinese medicine].Yao Xue Xue Bao. 2012 Jun;47(6):696-703. Yao Xue Xue Bao. 2012. PMID: 22919715 Review. Chinese.
-
[Network pharmacology: new guidelines for drug discovery].Yao Xue Xue Bao. 2010 Dec;45(12):1472-7. Yao Xue Xue Bao. 2010. PMID: 21351485 Review. Chinese.
-
[Network target: a starting point for traditional Chinese medicine network pharmacology].Zhongguo Zhong Yao Za Zhi. 2011 Aug;36(15):2017-20. Zhongguo Zhong Yao Za Zhi. 2011. PMID: 22066431 Review. Chinese.
-
Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction.J Ethnopharmacol. 2013 Nov 25;150(2):619-38. doi: 10.1016/j.jep.2013.09.018. Epub 2013 Sep 21. J Ethnopharmacol. 2013. PMID: 24064232
Cited by
-
Potential common mechanism of four Chinese patent medicines recommended by diagnosis and treatment protocol for COVID-19 in medical observation period.Front Med (Lausanne). 2022 Oct 26;9:874611. doi: 10.3389/fmed.2022.874611. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36388945 Free PMC article.
-
Exploration of anti‑osteosarcoma activity of asiatic acid based on network pharmacology and in vitro experiments.Oncol Rep. 2024 Feb;51(2):33. doi: 10.3892/or.2023.8692. Epub 2024 Jan 8. Oncol Rep. 2024. PMID: 38186298 Free PMC article.
-
Network Pharmacology-Based Analysis of Pogostemon cablin (Blanco) Benth Beneficial Effects to Alleviate Nonalcoholic Fatty Liver Disease in Mice.Front Pharmacol. 2021 Nov 24;12:789430. doi: 10.3389/fphar.2021.789430. eCollection 2021. Front Pharmacol. 2021. PMID: 34899351 Free PMC article.
-
Network analysis for elucidating the mechanisms of Shenfu injection in preventing and treating COVID-19 combined with heart failure.Comput Biol Med. 2022 Sep;148:105845. doi: 10.1016/j.compbiomed.2022.105845. Epub 2022 Jul 14. Comput Biol Med. 2022. PMID: 35849948 Free PMC article.
-
Antitumor Mechanisms of Curcumae Rhizoma Based on Network Pharmacology.Evid Based Complement Alternat Med. 2018 Feb 5;2018:4509892. doi: 10.1155/2018/4509892. eCollection 2018. Evid Based Complement Alternat Med. 2018. PMID: 29636777 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
