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. 2014 Nov;10(11):642-4.
doi: 10.1038/nrendo.2014.141. Epub 2014 Aug 12.

Obesity: cerebral damage in obesity-associated metabolic syndrome

Henry Rusinek  1 , Antonio Convit  2
Affiliations

Obesity: cerebral damage in obesity-associated metabolic syndrome

Henry Rusinek et al. Nat Rev Endocrinol. 2014 Nov.

Abstract

The prevalence of the metabolic syndrome has increased in tandem with that of obesity. The metabolic syndrome is associated with structural and functional cerebral damage. A new study confirms the association between the metabolic syndrome and reduced brain volume in the absence of diabetes mellitus. Here, we highlight how vascular dysfunction potentially contributes to this brain damage.

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Conflict of interest statement

Competing interests: The authors declare no competing interests

Figures

Figure 1
Figure 1
Glucose metabolism in the brain. Glucose is transported from the blood to the brain via GLUT1. Regional activation of the brain leads to local reductions in interstitial glucose levels, which are compensated via capillary recruitment leading to increased capillary density.
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References

    1. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA. 2012;307:491–497. - PubMed
    1. National Cholesterol Education Program (NCEP) expert panel on detection evaluation treatment of high blood cholesterol in adults (Adult Treament Panel III). Third report of the National Cholesterol Education Program (NCEP) expert panel on detection evaluation treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143–3421. - PubMed
    1. Ervin RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003–2006. Natl Health Stat Report. 2009;5:1–7. - PubMed
    1. Tiehuis AM, et al. Metabolic syndrome, prediabetes, and brain abnormalities on MRI in patients with manifest arterial disease: the SMART-MR study. Diabetes Care. 2014 http://dx.doi.org/10.2337/dc14-0154. - DOI - PubMed
    1. Dekaban AS. Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Ann Neurol. 1978;4:345–356. - PubMed

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