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. 2014 Sep 25;50(74):10849-52.
doi: 10.1039/c4cc03745f.

Enantioselective adsorption of ibuprofen and lysine in metal-organic frameworks

Rocio Bueno-Perez  1 , Ana Martin-Calvo, Paula Gómez-Álvarez, Juan J Gutiérrez-Sevillano, Patrick J Merkling, Thijs J H Vlugt, Titus S van Erp, David Dubbeldam, Sofia Calero
Affiliations

Enantioselective adsorption of ibuprofen and lysine in metal-organic frameworks

Rocio Bueno-Perez et al. Chem Commun (Camb). .

Abstract

This study reveals the efficient enantiomeric separation of bioactive molecules in the liquid phase. Chiral structure HMOF-1 separates racemic mixtures whereas heteroselectivity is observed for scalemic mixtures of ibuprofen using non-chiral MIL-47 and MIL-53. Lysine enantiomers are only separated by HMOF-1. These separations are controlled by the tight confinement of the molecules.

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