INO80 and SWR complexes: relating structure to function in chromatin remodeling
- PMID: 25088669
- DOI: 10.1016/j.tcb.2014.06.004
INO80 and SWR complexes: relating structure to function in chromatin remodeling
Abstract
Virtually all DNA-dependent processes require selective and controlled access to the DNA sequence. Governing this access are sophisticated molecular machines, nucleosome remodelers, which regulate the composition and structure of chromatin, allowing conversion from open to closed states. In most cases these multisubunit remodelers operate in concert to organize chromatin structure by depositing, moving, evicting, or selectively altering nucleosomes in an ATP-dependent manner. Despite sharing a conserved domain architecture, chromatin remodelers differ significantly in how they bind to their nucleosomal substrates. Recent structural studies link specific interactions between nucleosomes and remodelers to the diverse tasks they carry out. We review here insights into the modular organization of the INO80 family of nucleosome remodelers. Understanding their structural diversity will help to shed light on how these related ATPases modify their nucleosomal substrates.
Keywords: Arp subcomplexes; INO80-C; SWR-C; chromatin remodeling; nucleosome binding.
Copyright © 2014 Elsevier Ltd. All rights reserved.
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