Identifying and meeting the challenges of insulin therapy in type 2 diabetes
- PMID: 25061317
- PMCID: PMC4086769
- DOI: 10.2147/JMDH.S64084
Identifying and meeting the challenges of insulin therapy in type 2 diabetes
Abstract
Type 2 diabetes mellitus (T2DM) is a chronic illness that requires clinical recognition and treatment of the dual pathophysiologic entities of altered glycemic control and insulin resistance to reduce the risk of long-term micro- and macrovascular complications. Although insulin is one of the most effective and widely used therapeutic options in the management of diabetes, it is used by less than one-half of patients for whom it is recommended. Clinician-, patient-, and health care system-related challenges present numerous obstacles to insulin use in T2DM. Clinicians must remain informed about new insulin products, emerging technologies, and treatment options that have the potential to improve adherence to insulin therapy while optimizing glycemic control and mitigating the risks of therapy. Patient-related challenges may be overcome by actively listening to the patient's fears and concerns regarding insulin therapy and by educating patients about the importance, rationale, and evolving role of insulin in individualized self-treatment regimens. Enlisting the services of Certified Diabetes Educators and office personnel can help in addressing patient-related challenges. Self-management of diabetes requires improved patient awareness regarding the importance of lifestyle modifications, self-monitoring, and/or continuous glucose monitoring, improved methods of insulin delivery (eg, insulin pens), and the enhanced convenience and safety provided by insulin analogs. Health care system-related challenges may be improved through control of the rising cost of insulin therapy while making it available to patients. To increase the success rate of treatment of T2DM, the 2012 position statement from the American Diabetes Association and the European Association for the Study of Diabetes focused on individualized patient care and provided clinicians with general treatment goals, implementation strategies, and tools to evaluate the quality of care.
Keywords: barriers; emerging technologies; individualized therapy; insulin; insulin analogs; insulin pens; patient education; self-management; type 2 diabetes.
Similar articles
-
Internet and information technology use in treatment of diabetes.Int J Clin Pract Suppl. 2010 Feb;(166):41-6. doi: 10.1111/j.1742-1241.2009.02277.x. Int J Clin Pract Suppl. 2010. PMID: 20377663 Review.
-
Physiologic and weight-focused treatment strategies for managing type 2 diabetes mellitus: the metformin, glucagon-like peptide-1 receptor agonist, and insulin (MGI) approach.Postgrad Med. 2013 May;125(3):112-26. doi: 10.3810/pgm.2013.05.2666. Postgrad Med. 2013. PMID: 23748512 Review.
-
Considerations for diabetes: treatment with insulin pen devices.Am J Ther. 2013 Nov-Dec;20(6):694-702. doi: 10.1097/MJT.0b013e318217a5e3. Am J Ther. 2013. PMID: 21768872 Review.
-
Managing type 2 diabetes: going beyond glycemic control.J Manag Care Pharm. 2008 Jun;14(5 Suppl B):s2-19. J Manag Care Pharm. 2008. PMID: 18597582
-
A new look at established therapies: practical tools for optimizing insulin use.Diabetes Educ. 2010 May-Jun;36 Suppl 2:26S-38S; quiz 39S-40S. doi: 10.1177/0145721710369637. Diabetes Educ. 2010. PMID: 20511533
Cited by
-
Insulin Matters: A Practical Approach to Basal Insulin Management in Type 2 Diabetes.Diabetes Ther. 2018 Apr;9(2):501-519. doi: 10.1007/s13300-018-0375-7. Epub 2018 Feb 23. Diabetes Ther. 2018. PMID: 29476414 Free PMC article.
-
The SWEET SPOTS study: a real-world interpretation of the 2012 American Diabetes Association Position Statement regarding individualized A1C targets.Risk Manag Healthc Policy. 2016 Nov 8;9:243-251. doi: 10.2147/RMHP.S116800. eCollection 2016. Risk Manag Healthc Policy. 2016. PMID: 27877071 Free PMC article.
-
A Practitioner's Toolkit for Insulin Motivation in Adults with Type 1 and Type 2 Diabetes Mellitus: Evidence-Based Recommendations from an International Expert Panel.Diabetes Ther. 2020 Mar;11(3):585-606. doi: 10.1007/s13300-020-00764-7. Epub 2020 Jan 24. Diabetes Ther. 2020. PMID: 31981212 Free PMC article. Review.
-
Once-weekly Insulin Icodec Versus Once-daily Long-acting Insulin for Type II Diabetes: A Meta-analysis of Randomized Controlled Trials.J Endocr Soc. 2023 Dec 28;8(2):bvad177. doi: 10.1210/jendso/bvad177. eCollection 2024 Jan 5. J Endocr Soc. 2023. PMID: 38213906 Free PMC article. Review.
-
Predictors of Clinical Inertia and Type 2 Diabetes: Assessment of Primary Care Physicians and Their Patients.Int J Environ Res Public Health. 2022 Apr 7;19(8):4436. doi: 10.3390/ijerph19084436. Int J Environ Res Public Health. 2022. PMID: 35457303 Free PMC article.
References
-
- Heller S, Kozlovski P, Kurtzhals P. Insulin’s 85th anniversary – An enduring medical miracle. Diabetes Res Clin Pract. 2007;78(2):149–158. - PubMed
-
- Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA. 1999;281(21):2005–2012. - PubMed
-
- UKPDS 28: a randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes. UK Prospective Diabetes Study Group. Diabetes Care. 1998;21(1):87–92. - PubMed
-
- Weng J, Li Y, Xu W, et al. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet. 2008;371(9626):1753–1760. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources