Progress toward prevention of transfusion-transmitted hepatitis B and hepatitis C infection--sub-Saharan Africa, 2000-2011
- PMID: 25055184
- PMCID: PMC5779426
Progress toward prevention of transfusion-transmitted hepatitis B and hepatitis C infection--sub-Saharan Africa, 2000-2011
Abstract
Infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) are major causes of morbidity and mortality globally, primarily because of sequelae of chronic liver disease including cirrhosis and hepatocellular carcinoma. The risks for HBV and HCV transmission via blood transfusions have been described previously and are believed to be higher in countries in sub-Saharan Africa. Reducing the risk for transfusion-transmitted human immunodeficiency virus (HIV), HBV, and HCV infection is a priority for international aid organizations, such as the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), the Global Fund to Combat HIV/AIDS, Malaria, and Tuberculosis, and the World Health Organization (WHO). Over the last decade, PEPFAR and the Global Fund have supported blood safety programs in many sub-Saharan African countries with heavy burdens of HIV and acquired immunodeficiency syndrome (AIDS), hepatitis, malaria, and maternal mortality. This report summarizes HBV- and HCV-related surveillance data reported by the blood transfusion services of WHO member states to WHO's Global Database on Blood Safety (GDBS) (4). It also evaluates the performance of blood safety programs in screening for HBV and HCV in 38 sub-Saharan Africa countries. Selected GDBS indicators were compared for the years 2000 and 2004 (referred to as the 2000/2004 period) and 2010 and 2011 (referred to as the 2010/2011 period). From 2000/2004 to 2010/2011, the median of the annual number of units donated per country increased, the number of countries screening at least 95% of blood donations for HBV and HCV increased, and the median of the national prevalence of HBV and HCV marker-reactive blood donations decreased. These findings suggest that during the past decade, more blood has been donated and screened for HBV and HCV, resulting in a safer blood supply. Investments in blood safety should be continued to further increase the availability and safety of blood products in sub-Saharan Africa.
Figures
![FIGURE 1](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5779426/17dc3854560a/613-619f1.gif)
![FIGURE 2](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/135c/5779426/addf2788b12f/613-619f2.gif)
Similar articles
-
The risk of transfusion-transmitted infections in sub-Saharan Africa.Transfusion. 2010 Feb;50(2):433-42. doi: 10.1111/j.1537-2995.2009.002402.x. Epub 2009 Oct 15. Transfusion. 2010. PMID: 19843290 Review.
-
Safety of blood supply in the Caribbean countries: role of screening blood donors for markers of hepatitis B and C viruses.J Clin Virol. 2005 Dec;34 Suppl 2:S75-80. doi: 10.1016/s1386-6532(05)80038-1. J Clin Virol. 2005. PMID: 16461244
-
Prevalence and Trends of Transfusion-Transmissible Viral Infections among Blood Donors in South of Iran: An Eleven-Year Retrospective Study.PLoS One. 2016 Jun 16;11(6):e0157615. doi: 10.1371/journal.pone.0157615. eCollection 2016. PLoS One. 2016. PMID: 27309959 Free PMC article.
-
Residual risk of transfusion-transmitted infection with human immunodeficiency virus, hepatitis C virus, and hepatitis B virus in Korea from 2000 through 2010.BMC Infect Dis. 2012 Jul 20;12:160. doi: 10.1186/1471-2334-12-160. BMC Infect Dis. 2012. PMID: 22817275 Free PMC article.
-
Hepatitis B/C and HIV in sub-Saharan Africa: an association between highly prevalent infectious diseases. A systematic review and meta-analysis.Int J Infect Dis. 2010 Dec;14(12):e1024-31. doi: 10.1016/j.ijid.2010.06.013. Epub 2010 Sep 25. Int J Infect Dis. 2010. PMID: 20870439 Review.
Cited by
-
Apheresis for collection of Ebola convalescent plasma in Liberia.J Clin Apher. 2017 Jun;32(3):175-181. doi: 10.1002/jca.21482. Epub 2016 Jul 8. J Clin Apher. 2017. PMID: 27393614 Free PMC article.
-
Trends in hepatitis B and hepatitis C seroprevalence among blood donors - Haiti, 2005-2014.ISBT Sci Ser. 2018 May;13(2):150-157. doi: 10.1111/voxs.12427. Epub 2018 Mar 22. ISBT Sci Ser. 2018. PMID: 30613210 Free PMC article.
-
Malignancy and viral infections in Sub-Saharan Africa: A review.Front Virol. 2023;3:1103737. doi: 10.3389/fviro.2023.1103737. Epub 2023 Mar 6. Front Virol. 2023. PMID: 37476029 Free PMC article.
-
Prognostic Value of Stem Cell Index-Related Characteristics in Primary Hepatocellular Carcinoma.Contrast Media Mol Imaging. 2022 Jun 8;2022:2672033. doi: 10.1155/2022/2672033. eCollection 2022. Contrast Media Mol Imaging. 2022. Retraction in: Contrast Media Mol Imaging. 2023 Jul 19;2023:9850917. doi: 10.1155/2023/9850917 PMID: 35800238 Free PMC article. Retracted.
-
Transfusion-transmissible viral infections among blood donors at the North Gondar district blood bank, northwest Ethiopia: A three year retrospective study.PLoS One. 2017 Jul 5;12(7):e0180416. doi: 10.1371/journal.pone.0180416. eCollection 2017. PLoS One. 2017. PMID: 28678865 Free PMC article.
References
-
- Te H, Jensen D. Epidemiology of hepatitis B and C viruses: a global overview. Clin Liver Dis. 2010;14:1–21. - PubMed
-
- Alter HJ, Purcell RH, Shih JW, et al. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med. 1989;321:1494–500. - PubMed
-
- Jayaraman S, Chalabi Z, Perel P, et al. The risk of transfusion-transmitted infections in sub-Saharan Africa. Transfusion. 2010;50:433–42. - PubMed
-
- World Health Organization. Global Database on Blood Safety. Geneva, Switzerland: World Health Organization; 2013. Available at http://www.who.int/bloodsafety/global_database.
-
- CDC. Progress toward strengthening national blood transfusion services—14 countries, 2008–2010. MMWR. 2011;60:1578–82. - PubMed
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous