Mesenchymal stem cells and hypoxia: where are we?

doi:10.1016/j.mito.2014.07.005

Review

. 2014 Nov:19 Pt A:105-12.

doi: 10.1016/j.mito.2014.07.005. Epub 2014 Jul 15.

Mesenchymal stem cells and hypoxia: where are we?

L B Buravkova¹, E R Andreeva², V Gogvadze³, B Zhivotovsky⁴

Affiliations

¹ Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia; Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia.
² Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
³ Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden.
⁴ Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden. Electronic address: Boris.Zhivotovsky@ki.se.

PMID: 25034305
DOI: 10.1016/j.mito.2014.07.005

Review

Mesenchymal stem cells and hypoxia: where are we?

L B Buravkova et al. Mitochondrion. 2014 Nov.

. 2014 Nov:19 Pt A:105-12.

doi: 10.1016/j.mito.2014.07.005. Epub 2014 Jul 15.

Authors

L B Buravkova¹, E R Andreeva², V Gogvadze³, B Zhivotovsky⁴

Affiliations

¹ Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia; Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia.
² Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
³ Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden.
⁴ Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden. Electronic address: Boris.Zhivotovsky@ki.se.

PMID: 25034305
DOI: 10.1016/j.mito.2014.07.005

Abstract

Multipotent mesenchymal stromal cells (MSCs) are involved in the organization and maintenance of tissue integrity. MSCs have also attracted attention as a promising tool for cell therapy and regenerative medicine. However, their usage is limited due to cell impairment induced by an extremely harsh microenvironment during transplantation ex vivo. The microenvironment of MSCs in tissue depots is characterized by rather low oxygen consumption, demonstrating that MSCs might be quite resistant to oxygen limitation. However, accumulated data revealed that the response of MSCs to hypoxic conditions is rather controversial, demonstrating both damaging and ameliorating effects. Here, we make an attempt to summarize recent knowledge on the survival of MSCs under low oxygen conditions of varying duration and severity and to elucidate the mechanisms of MSC resistance/sensitivity to hypoxic impact.

Keywords: Cell death; Hypoxia; Mesenchymal stem cells; Mitochondria.

PubMed Disclaimer

Cited by

Peroxisome Proliferator-Activated Receptor Gamma Promotes Mesenchymal Stem Cells to Express Connexin43 via the Inhibition of TGF-β1/Smads Signaling in a Rat Model of Myocardial Infarction.
Hou J, Wang L, Hou J, Guo T, Xing Y, Zheng S, Zhou C, Huang H, Long H, Zhong T, Wu Q, Wang J, Wang T. Hou J, et al. Stem Cell Rev Rep. 2015 Dec;11(6):885-99. doi: 10.1007/s12015-015-9615-7. Stem Cell Rev Rep. 2015. PMID: 26275398
Characteristics of Human Nasal Turbinate Stem Cells under Hypoxic Conditions.
Kim DH, Kim SH, Park SH, Kwon MY, Lim CY, Park SH, Gwon K, Hwang SH, Kim SW. Kim DH, et al. Cells. 2023 Sep 26;12(19):2360. doi: 10.3390/cells12192360. Cells. 2023. PMID: 37830573 Free PMC article.
In Vitro Innovation of Tendon Tissue Engineering Strategies.
Citeroni MR, Ciardulli MC, Russo V, Della Porta G, Mauro A, El Khatib M, Di Mattia M, Galesso D, Barbera C, Forsyth NR, Maffulli N, Barboni B. Citeroni MR, et al. Int J Mol Sci. 2020 Sep 14;21(18):6726. doi: 10.3390/ijms21186726. Int J Mol Sci. 2020. PMID: 32937830 Free PMC article. Review.
Cellular microenvironment: a key for tuning mesenchymal stem cell senescence.
Sun W, Lv J, Guo S, Lv M. Sun W, et al. Front Cell Dev Biol. 2023 Dec 4;11:1323678. doi: 10.3389/fcell.2023.1323678. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 38111850 Free PMC article. Review.
HIF1α-mediated AIMP3 suppression delays stem cell aging via the induction of autophagy.
Kim C, Park JM, Song Y, Kim S, Moon J. Kim C, et al. Aging Cell. 2019 Apr;18(2):e12909. doi: 10.1111/acel.12909. Epub 2019 Jan 31. Aging Cell. 2019. PMID: 30706629 Free PMC article.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Mesenchymal stem cells and hypoxia: where are we?

Affiliations

Mesenchymal stem cells and hypoxia: where are we?

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources