Regulatory T cells inhibit microglia activation and protect against inflammatory injury in intracerebral hemorrhage
- PMID: 25000335
- DOI: 10.1016/j.intimp.2014.06.037
Regulatory T cells inhibit microglia activation and protect against inflammatory injury in intracerebral hemorrhage
Abstract
Numerous evidence demonstrate that microglia mediated inflammatory injury plays a critical role in intracerebral hemorrhage (ICH). Therefore, the way to inhibit the inflammatory response is greatly needed. Treg cells have been shown to play a critical role in immunologic self-tolerance as well as anti-tumor immune responses and transplantation. In the current study, we transfered Treg cells in the ICH model, and investigated the effect. The cytokines of microglia were measured by ELISA, JNK/ERK and NF-κB were measured by Western blot and EMSA (Electrophoretic Mobility Shift Assay), animal behavior was evaluated by animal behavioristics. We found that Treg cells could inhibit microglia mediated inflammatory response through NF-κB activation via the JNK/ERK pathway in vitro, and improve neurological function in vivo. Our findings suggest that Treg cells could suppress inflammatory injury and represent a novel cell-based therapeutical strategy in ICH.
Keywords: Inflammatory injury; Intracerebral hemorrhage; Microglia; Regulatory T cells.
Copyright © 2014. Published by Elsevier B.V.
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