Bacterial neuroactive compounds produced by psychobiotics
- PMID: 24997036
- DOI: 10.1007/978-1-4939-0897-4_10
Bacterial neuroactive compounds produced by psychobiotics
Abstract
We recently coined the phrase 'psychobiotics' to describe an emerging class of probiotics of relevance to psychiatry [Dinan et al., Biol Psychiatry 2013;74(10):720-726]. Such "mind-altering" probiotics may act via their ability to produce various biologically active compounds, such as peptides and mediators normally associated with mammalian neurotransmission. Several molecules with neuroactive functions such as gamma-aminobutyric acid (GABA), serotonin, catecholamines and acetylcholine have been reported to be microbially-derived, many of which have been isolated from bacteria within the human gut. Secreted neurotransmitters from bacteria in the intestinal lumen may induce epithelial cells to release molecules that in turn modulate neural signalling within the enteric nervous system and consequently signal brain function and behaviour of the host. Consequently, neurochemical containing/producing probiotic bacteria may be viewed as delivery vehicles for neuroactive compounds and as such, probiotic bacteria may possibly have the potential as a therapeutic strategy in the prevention and/or treatment of certain neurological and neurophysiological conditions.
Similar articles
-
Gut microbiota, the pharmabiotics they produce and host health.Proc Nutr Soc. 2014 Nov;73(4):477-89. doi: 10.1017/S0029665114001426. Epub 2014 Sep 8. Proc Nutr Soc. 2014. PMID: 25196939 Review.
-
From Probiotics to Psychobiotics: Live Beneficial Bacteria Which Act on the Brain-Gut Axis.Nutrients. 2019 Apr 20;11(4):890. doi: 10.3390/nu11040890. Nutrients. 2019. PMID: 31010014 Free PMC article. Review.
-
Psychobiotics: a novel class of psychotropic.Biol Psychiatry. 2013 Nov 15;74(10):720-6. doi: 10.1016/j.biopsych.2013.05.001. Epub 2013 Jun 10. Biol Psychiatry. 2013. PMID: 23759244 Review.
-
Role of Neurochemicals in the Interaction between the Microbiota and the Immune and the Nervous System of the Host Organism.Probiotics Antimicrob Proteins. 2017 Sep;9(3):215-234. doi: 10.1007/s12602-017-9262-1. Probiotics Antimicrob Proteins. 2017. PMID: 28229287 Review.
-
Gut production of GABA by a probiotic formula: an in vitro study.Benef Microbes. 2024 Jan 4;15(1):67-81. doi: 10.1163/18762891-20230025. Benef Microbes. 2024. PMID: 38350463
Cited by
-
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration.J Physiol. 2017 Jan 15;595(2):489-503. doi: 10.1113/JP273106. Epub 2016 Dec 4. J Physiol. 2017. PMID: 27641441 Free PMC article. Review.
-
A Combination Supplement of Fructo- and Xylo-Oligosaccharides Significantly Abrogates Oxidative Impairments and Neurotoxicity in Maternal/Fetal Milieu Following Gestational Exposure to Acrylamide in Rat.Neurochem Res. 2015 Sep;40(9):1904-18. doi: 10.1007/s11064-015-1687-x. Epub 2015 Aug 7. Neurochem Res. 2015. PMID: 26248513
-
Evidence for dopamine production and distribution of dopamine D2 receptors in the equine gastrointestinal mucosa and pancreas.PLoS One. 2024 Feb 27;19(2):e0298660. doi: 10.1371/journal.pone.0298660. eCollection 2024. PLoS One. 2024. PMID: 38412155 Free PMC article.
-
Human milk oligosaccharide 2'-fucosyllactose links feedings at 1 month to cognitive development at 24 months in infants of normal and overweight mothers.PLoS One. 2020 Feb 12;15(2):e0228323. doi: 10.1371/journal.pone.0228323. eCollection 2020. PLoS One. 2020. PMID: 32049968 Free PMC article.
-
Specialized metabolites from the microbiome in health and disease.Cell Metab. 2014 Nov 4;20(5):719-730. doi: 10.1016/j.cmet.2014.10.016. Epub 2014 Nov 4. Cell Metab. 2014. PMID: 25440054 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
