doi: 10.1016/j.ddtec.2004.10.008.
Metabolic screening in vitro: metabolic stability, CYP inhibition and induction
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- PMID: 24981616
- DOI: 10.1016/j.ddtec.2004.10.008
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Metabolic screening in vitro: metabolic stability, CYP inhibition and induction
Drug Discov Today Technol.
2004 Dec.
Abstract
Automated, miniaturised assays are now commonplace within Discovery DMPK (drug metabolism and pharmacokinetics). These have evolved considerably since their inception around a decade ago, in-line with both technology and the desire to provide quality data comparable to more traditional analyses. Several formats exist for routine screening of metabolic stability and cyp (cytochrome P450; see Glossary) inhibition and induction, with the major focus being on in vitro systems using human-derived material. Data from other species remain valuable in assessing in vitro-in vivo projections and are pivotal to support safety assessment studies.:
© 2004 Elsevier Ltd . All rights reserved.
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