Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

doi:10.1128/AAC.02889-14

Randomized Controlled Trial

. 2014 Aug;58(8):4971-3.

doi: 10.1128/AAC.02889-14. Epub 2014 Jun 9.

Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Affiliations

¹ Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
² Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
³ Infectious Diseases Research Collaboration, Kampala, Uganda.
⁴ Infectious Diseases Research Collaboration, Kampala, Uganda Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
⁵ Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁶ Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom teun.bousema@lshtm.ac.uk.

PMID: 24913169
PMCID: PMC4136063
DOI: 10.1128/AAC.02889-14

Randomized Controlled Trial

Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Alice C Eziefula et al. Antimicrob Agents Chemother. 2014 Aug.

. 2014 Aug;58(8):4971-3.

doi: 10.1128/AAC.02889-14. Epub 2014 Jun 9.

Authors

Affiliations

¹ Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
² Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
³ Infectious Diseases Research Collaboration, Kampala, Uganda.
⁴ Infectious Diseases Research Collaboration, Kampala, Uganda Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
⁵ Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁶ Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom teun.bousema@lshtm.ac.uk.

PMID: 24913169
PMCID: PMC4136063
DOI: 10.1128/AAC.02889-14

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

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References

1. White NJ. 2013. Primaquine to prevent transmission of falciparum malaria. Lancet Infect. Dis. 13:175–181. 10.1016/S1473-3099(12)70198-6 - DOI - PubMed
1. Alving AS, Carson PE, Flanagan CL, Ickes CE. 1956. Enzymatic deficiency in primaquine-sensitive erythrocytes. Science 124:484–485. 10.1126/science.124.3220.484 - DOI - PubMed
1. Beutler E, Yeh M, Fairbanks VF. 1962. The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker. Proc. Natl. Acad. Sci. U. S. A. 48:9–16. 10.1073/pnas.48.1.9 - DOI - PMC - PubMed
1. Beutler E. 1959. The hemolytic effect of primaquine and related compounds: a review. Blood 14:103–139 - PubMed
1. Alving AS, Johnson CF, Tarlov AR, Brewer GJ, Kellermeyer RW, Carson PE. 1960. Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Plasmodium vivax by intermittent regimens of drug administration: a preliminary report. Bull. World Health Organ. 22:621–631 - PMC - PubMed

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[1] White NJ. 2013. Primaquine to prevent transmission of falciparum malaria. Lancet Infect. Dis. 13:175–181. 10.1016/S1473-3099(12)70198-6 - DOI - PubMed

[2] White NJ. 2013. Primaquine to prevent transmission of falciparum malaria. Lancet Infect. Dis. 13:175–181. 10.1016/S1473-3099(12)70198-6 - DOI - PubMed

[3] Alving AS, Carson PE, Flanagan CL, Ickes CE. 1956. Enzymatic deficiency in primaquine-sensitive erythrocytes. Science 124:484–485. 10.1126/science.124.3220.484 - DOI - PubMed

[4] Alving AS, Carson PE, Flanagan CL, Ickes CE. 1956. Enzymatic deficiency in primaquine-sensitive erythrocytes. Science 124:484–485. 10.1126/science.124.3220.484 - DOI - PubMed

[5] Beutler E, Yeh M, Fairbanks VF. 1962. The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker. Proc. Natl. Acad. Sci. U. S. A. 48:9–16. 10.1073/pnas.48.1.9 - DOI - PMC - PubMed

[6] Beutler E, Yeh M, Fairbanks VF. 1962. The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker. Proc. Natl. Acad. Sci. U. S. A. 48:9–16. 10.1073/pnas.48.1.9 - DOI - PMC - PubMed

[7] Beutler E. 1959. The hemolytic effect of primaquine and related compounds: a review. Blood 14:103–139 - PubMed

[8] Beutler E. 1959. The hemolytic effect of primaquine and related compounds: a review. Blood 14:103–139 - PubMed

[9] Alving AS, Johnson CF, Tarlov AR, Brewer GJ, Kellermeyer RW, Carson PE. 1960. Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Plasmodium vivax by intermittent regimens of drug administration: a preliminary report. Bull. World Health Organ. 22:621–631 - PMC - PubMed

[10] Alving AS, Johnson CF, Tarlov AR, Brewer GJ, Kellermeyer RW, Carson PE. 1960. Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Plasmodium vivax by intermittent regimens of drug administration: a preliminary report. Bull. World Health Organ. 22:621–631 - PMC - PubMed

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Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Affiliations

Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

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Abstract

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