Review
doi: 10.1016/j.coph.2014.05.001.
Epub 2014 Jun 5.
Role of miRNAs in bone and their potential as therapeutic targets
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- PMID: 24907412
- DOI: 10.1016/j.coph.2014.05.001
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Review
Role of miRNAs in bone and their potential as therapeutic targets
Curr Opin Pharmacol.
2014 Jun.
Abstract
MicroRNAs (miRNAs) are noncoding, single-stranded RNAs that regulate the expression of target genes by binding their 3'-untranslated region. miRNAs are important regulators of various biological processes, including cellular differentiation, proliferation, apoptosis, and tissue development. Furthermore, aberrant miRNA expression has emerged as an important pathomechanism in various human diseases, including osteoporosis. Thus, the therapeutic potential of miRNA has attracted great interest recently. Here, we focused on the roles of miRNAs in bone homeostasis and the potential of miRNAs as therapeutic targets.
Copyright © 2014 Elsevier Ltd. All rights reserved.
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