A computational model that predicts reverse growth in response to mechanical unloading
- PMID: 24888270
- PMCID: PMC4254895
- DOI: 10.1007/s10237-014-0598-0
A computational model that predicts reverse growth in response to mechanical unloading
Abstract
Ventricular growth is widely considered to be an important feature in the adverse progression of heart diseases, whereas reverse ventricular growth (or reverse remodeling) is often considered to be a favorable response to clinical intervention. In recent years, a number of theoretical models have been proposed to model the process of ventricular growth while little has been done to model its reverse. Based on the framework of volumetric strain-driven finite growth with a homeostatic equilibrium range for the elastic myofiber stretch, we propose here a reversible growth model capable of describing both ventricular growth and its reversal. We used this model to construct a semi-analytical solution based on an idealized cylindrical tube model, as well as numerical solutions based on a truncated ellipsoidal model and a human left ventricular model that was reconstructed from magnetic resonance images. We show that our model is able to predict key features in the end-diastolic pressure-volume relationship that were observed experimentally and clinically during ventricular growth and reverse growth. We also show that the residual stress fields generated as a result of differential growth in the cylindrical tube model are similar to those in other nonidentical models utilizing the same geometry.
Figures
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References
-
- Brinke EA, Klautz RJ, Tulner SA, Verwey HF, Bax JJ, Delgado V, Holman ER, Schalij MJ, van der Wall EE, Braun J, Versteegh MI, Dion RA, Steendijk P. Clinical and functional effects of restrictive mitral annuloplasty at midterm follow-up in heart failure patients. Ann Thorac Surg. 2010;90(6):1913–1920. - PubMed
-
- Burkhoff D, Klotz S, Mancini DM. LVAD-induced reverse remodeling: basic and clinical implications for myocardial recovery. J Card Fail. 2006;12(3):227–239. - PubMed
-
- Choi HF, D'hooge J, Rademakers FE, Claus P. Influence of left-ventricular shape on passive filling properties and end-diastolic fiber stress and strain. J Biomech. 2010;43(9):1745–1753. - PubMed
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