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Review
. 2014:2014:979730.
doi: 10.1155/2014/979730. Epub 2014 Apr 23.

Recent updates in the treatment of neurodegenerative disorders using natural compounds

Mahmood Rasool  1 , Arif Malik  2 , Muhammad Saeed Qureshi  3 , Abdul Manan  2 , Peter Natesan Pushparaj  1 , Muhammad Asif  4 , Mahmood Husain Qazi  5 , Aamer Mahmood Qazi  6 , Mohammad Amjad Kamal  7 , Siew Hua Gan  8 , Ishfaq Ahmed Sheikh  7
Affiliations
Review

Recent updates in the treatment of neurodegenerative disorders using natural compounds

Mahmood Rasool et al. Evid Based Complement Alternat Med. 2014.

Abstract

Neurodegenerative diseases are characterized by protein aggregates and inflammation as well as oxidative stress in the central nervous system (CNS). Multiple biological processes are linked to neurodegenerative diseases such as depletion or insufficient synthesis of neurotransmitters, oxidative stress, abnormal ubiquitination. Furthermore, damaging of blood brain barrier (BBB) in the CNS also leads to various CNS-related diseases. Even though synthetic drugs are used for the management of Alzheimer's disease, Parkinson's disease, autism, and many other chronic illnesses, they are not without side effects. The attentions of researchers have been inclined towards the phytochemicals, many of which have minimal side effects. Phytochemicals are promising therapeutic agents because many phytochemicals have anti-inflammatory, antioxidative as well as anticholinesterase activities. Various drugs of either synthetic or natural origin applied in the treatment of brain disorders need to cross the BBB before they can be used. This paper covers various researches related to phytochemicals used in the management of neurodegenerative disorders.

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Figures

Figure 1
Figure 1
Various biological mechanisms contributing to neurodegenerative disorders.
Figure 2
Figure 2
Luteolin (flavonoid) responsible for multiple biological functions.
See this image and copyright information in PMC

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References

    1. Wong E, Cuervo AM. Autophagy gone awry in neurodegenerative diseases. Nature Neuroscience. 2010;13(7):805–811. - PMC - PubMed
    1. Ciechanover A. The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting. Neurology. 2006;66(2):7–19. - PubMed
    1. Aruoma OI, Bahorun T, Jen L-S. Neuroprotection by bioactive components in medicinal and food plant extracts. Mutation Research. 2003;544(2-3):203–215. - PubMed
    1. Jenner P, Olanow CW. Understanding cell death in Parkinson’s disease. Annals of Neurology. 1998;3(1):72–84. - PubMed
    1. Behl C. Alzheimer’s disease and oxidative stress: implications for novel therapeutic approaches. Progress in Neurobiology. 1999;57(3):301–323. - PubMed

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