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. 2014 Jul 15;272(1-2):99-102.
doi: 10.1016/j.jneuroim.2014.04.017. Epub 2014 May 10.

Monocytes and CD4+ T cells contribution to the under-expression of NR4A2 and TNFAIP3 genes in patients with multiple sclerosis

N D Navone  1 , S Perga  2 , S Martire  2 , P Berchialla  3 , S Malucchi  2 , A Bertolotto  4
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Free article

Monocytes and CD4+ T cells contribution to the under-expression of NR4A2 and TNFAIP3 genes in patients with multiple sclerosis

N D Navone et al. J Neuroimmunol. .
Free article

Abstract

We recently found a gene signature for multiple sclerosis (MS) that reverted to normal during pregnancy in MS patients and included NR4A2 and TNFAIP3, key molecules in anti-inflammatory processes. Here we focus on the expression levels of these two genes in monocytes and CD4+ T cells from healthy controls and treatment-naïve RRMS patients. Our findings show that monocytes play a key role in the dysregulated anti-inflammatory response, being the expression of both genes down-regulated in these cells in RRMS patients with respect to healthy individuals. CD4+ T cells seem to have only a marginal part, because we can observe only a slight down-regulation in NR4A2.

Keywords: CD4+ T cells; Monocytes; Multiple sclerosis; NR4A2; TNFAIP3.

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