Insights into RNA structure and function from genome-wide studies

doi:10.1038/nrg3681

Review

. 2014 Jul;15(7):469-79.

doi: 10.1038/nrg3681. Epub 2014 May 13.

Insights into RNA structure and function from genome-wide studies

Stefanie A Mortimer¹, Mary Anne Kidwell², Jennifer A Doudna³

Affiliations

¹ 1] Department of Molecular and Cell Biology, University of California, Berkeley. [2] Guardant Health, Inc., 2686 Middlefield Road, Redwood City, California 94063, USA. [3].
² 1] Department of Molecular and Cell Biology, University of California, Berkeley. [2].
³ 1] Department of Molecular and Cell Biology, University of California, Berkeley. [2] Howard Hughes Medical Institute, University of California, Berkeley. [3] Department of Chemistry, University of California, Berkeley, California 94720, USA. [4] Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

PMID: 24821474
DOI: 10.1038/nrg3681

Review

Insights into RNA structure and function from genome-wide studies

Stefanie A Mortimer et al. Nat Rev Genet. 2014 Jul.

. 2014 Jul;15(7):469-79.

doi: 10.1038/nrg3681. Epub 2014 May 13.

Authors

Stefanie A Mortimer¹, Mary Anne Kidwell², Jennifer A Doudna³

Affiliations

¹ 1] Department of Molecular and Cell Biology, University of California, Berkeley. [2] Guardant Health, Inc., 2686 Middlefield Road, Redwood City, California 94063, USA. [3].
² 1] Department of Molecular and Cell Biology, University of California, Berkeley. [2].
³ 1] Department of Molecular and Cell Biology, University of California, Berkeley. [2] Howard Hughes Medical Institute, University of California, Berkeley. [3] Department of Chemistry, University of California, Berkeley, California 94720, USA. [4] Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

PMID: 24821474
DOI: 10.1038/nrg3681

Abstract

A comprehensive understanding of RNA structure will provide fundamental insights into the cellular function of both coding and non-coding RNAs. Although many RNA structures have been analysed by traditional biophysical and biochemical methods, the low-throughput nature of these approaches has prevented investigation of the vast majority of cellular transcripts. Triggered by advances in sequencing technology, genome-wide approaches for probing the transcriptome are beginning to reveal how RNA structure affects each step of protein expression and RNA stability. In this Review, we discuss the emerging relationships between RNA structure and the regulation of gene expression.

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References

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[1] Mol Ther. 2012 Apr;20(4):820-8 - PubMed

[2] Mol Ther. 2012 Apr;20(4):820-8 - PubMed

[3] Nature. 2003 Oct 16;425(6959):737-41 - PubMed

[4] Nature. 2003 Oct 16;425(6959):737-41 - PubMed

[5] Mol Cell. 2012 Oct 26;48(2):169-81 - PubMed

[6] Mol Cell. 2012 Oct 26;48(2):169-81 - PubMed

[7] Nature. 2008 Apr 3;452(7187):598-603 - PubMed

[8] Nature. 2008 Apr 3;452(7187):598-603 - PubMed

[9] Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):85-92 - PubMed

[10] Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):85-92 - PubMed

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Insights into RNA structure and function from genome-wide studies

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Insights into RNA structure and function from genome-wide studies

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