Fibroblast growth factors
- PMID: 2480829
- DOI: 10.1093/oxfordjournals.bmb.a072333
Fibroblast growth factors
Abstract
The existence of fibroblast growth factors (FGFs) was proposed over 40 years ago to account for the ability of tissue extracts to stimulate fibroblast proliferation. In the 1970s it became clear that preparations containing FGF activity were in fact pleiotropic, affecting the growth and function of a wide variety of mesenchymal, endocrine and neural cells. Their angiogenic effects have promoted research in cardiology and neurology because of their proposed role in stimulating collateral vascularisation and recovery from ischemia. Their identity with a component of tumour angiogenesis factor activity has stimulated research in oncology and their capacity to enhance wound healing, nerve regeneration and cartilage repair has affected research in neurology, orthopaedic medicine and pathology. The potential therapeutic value of FGFs is just beginning to be realized and will be dependent on a concerted effort to establish their function in the regulation of normal cell homeostasis and the pathophysiology of disease.
Similar articles
-
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis.Cytokine Growth Factor Rev. 2005 Apr;16(2):159-78. doi: 10.1016/j.cytogfr.2005.01.004. Epub 2005 Feb 2. Cytokine Growth Factor Rev. 2005. PMID: 15863032 Review.
-
Humoral control of cell proliferation: the role of fibroblast growth factor in regeneration, angiogenesis, wound healing, and neoplastic growth.Prog Clin Biol Res. 1976;9:1-19. Prog Clin Biol Res. 1976. PMID: 1030795
-
Fibroblast growth factors: at the heart of angiogenesis.Cell Biol Int. 1995 May;19(5):431-44. doi: 10.1006/cbir.1995.1087. Cell Biol Int. 1995. PMID: 7543787 Review.
-
Basic fibroblast growth factor (FGF) promotes cartilage repair in vivo.Biochem Biophys Res Commun. 1988 Oct 31;156(2):611-8. doi: 10.1016/s0006-291x(88)80887-8. Biochem Biophys Res Commun. 1988. PMID: 3190672
-
FGFs and their receptors, in vitro and in vivo studies: new FGF receptor in the brain, FGF-1 in muscle, and the use of functional analogues of low-affinity heparin-binding growth factor receptors in tissue repair.Mol Reprod Dev. 1994 Sep;39(1):49-54; discussion 54-5. doi: 10.1002/mrd.1080390109. Mol Reprod Dev. 1994. PMID: 7528027 Review.
Cited by
-
Heparin-like glycosaminoglycans influence growth and phenotype of human arterial smooth muscle cells in vitro. I. Evidence for reversible binding and inactivation of the platelet-derived growth factor by heparin.In Vitro Cell Dev Biol. 1992 Mar;28A(3 Pt 1):168-75. doi: 10.1007/BF02631087. In Vitro Cell Dev Biol. 1992. PMID: 1582991
-
Molecular aspects of pathological processes in the artery wall.Mol Biol Rep. 1992 Nov;17(1):1-15. doi: 10.1007/BF01006394. Mol Biol Rep. 1992. PMID: 1287474 Review. No abstract available.
-
Advances in the management of leg ulcers--the potential role of growth factors.Int Wound J. 2006 Jun;3(2):113-20. doi: 10.1111/j.1742-4801.2006.00211.x. Int Wound J. 2006. PMID: 17007341 Free PMC article. Review.
-
A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation.PLoS One. 2014 Jul 17;9(7):e102739. doi: 10.1371/journal.pone.0102739. eCollection 2014. PLoS One. 2014. PMID: 25033458 Free PMC article.
-
Heparanase activity expressed by platelets, neutrophils, and lymphoma cells releases active fibroblast growth factor from extracellular matrix.Cell Regul. 1990 Oct;1(11):833-42. doi: 10.1091/mbc.1.11.833. Cell Regul. 1990. PMID: 2088528 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
