Drug resistance in leishmaniasis: Newer developments
- PMID: 24754020
- PMCID: PMC3992802
- DOI: 10.4103/2229-5070.129142
Drug resistance in leishmaniasis: Newer developments
Abstract
Leishmaniasis is a vector borne protozoan disease and it remains a major public health problem world-wide. Lack of an effective vaccine and vector control program makes the chemotherapy as the primary tool for leishmaniasis. Antimonials were used as the first line of treatment for many years. Emergence of resistance against this drug has become a major concern. Literatures and studies published on anti-leishmanial drug resistance, newer drug discovery for leishmanial resistance etc., in PubMed, Medline and Google search and reviewed thoroughly. Various newer drugs have been identified but, are in limited use because of high cost, toxicity, resistance etc., Recently, many newer mechanisms of drug resistance have been identified which may boost in future designing and development of drugs.
Keywords: Amphotericin B; antimonials; drug resistance; leishmaniasis; miltefocine; paromomycin.
Conflict of interest statement
Similar articles
-
Paromomycin in the treatment of leishmaniasis.Expert Opin Investig Drugs. 2008 May;17(5):787-94. doi: 10.1517/13543784.17.5.787. Expert Opin Investig Drugs. 2008. PMID: 18447603 Review.
-
Leishmaniasis: current status of available drugs and new potential drug targets.Asian Pac J Trop Med. 2012 Jun;5(6):485-97. doi: 10.1016/S1995-7645(12)60084-4. Asian Pac J Trop Med. 2012. PMID: 22575984 Review.
-
Drug resistance in visceral leishmaniasis.J Biomed Biotechnol. 2010;2010:617521. doi: 10.1155/2010/617521. Epub 2009 Nov 1. J Biomed Biotechnol. 2010. PMID: 19888437 Free PMC article. Review.
-
Interventions for Old World cutaneous leishmaniasis.Cochrane Database Syst Rev. 2017 Nov 17;11(11):CD005067. doi: 10.1002/14651858.CD005067.pub4. Cochrane Database Syst Rev. 2017. Update in: Cochrane Database Syst Rev. 2017 Dec 01;12:CD005067. doi: 10.1002/14651858.CD005067.pub5. PMID: 29149474 Free PMC article. Updated. Review.
-
Emerging role of amiodarone and dronedarone, as antiarrhythmic drugs, in treatment of leishmaniasis.Acta Trop. 2018 Sep;185:34-41. doi: 10.1016/j.actatropica.2018.04.022. Epub 2018 Apr 22. Acta Trop. 2018. PMID: 29689189 Review.
Cited by
-
Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17.ACS Infect Dis. 2024 Jun 14;10(6):2002-2017. doi: 10.1021/acsinfecdis.4c00009. Epub 2024 May 16. ACS Infect Dis. 2024. PMID: 38753953 Free PMC article.
-
Genomic Insight of Leishmania Parasite: In-Depth Review of Drug Resistance Mechanisms and Genetic Mutations.ACS Omega. 2024 Mar 8;9(11):12500-12514. doi: 10.1021/acsomega.3c09400. eCollection 2024 Mar 19. ACS Omega. 2024. PMID: 38524425 Free PMC article. Review.
-
Shifting from Ammonium to Phosphonium Salts: A Promising Strategy to Develop Next-Generation Weapons against Biofilms.Pharmaceutics. 2024 Jan 5;16(1):80. doi: 10.3390/pharmaceutics16010080. Pharmaceutics. 2024. PMID: 38258091 Free PMC article. Review.
-
Immunotherapy and immunochemotherapy in combating visceral leishmaniasis.Front Med (Lausanne). 2023 May 17;10:1096458. doi: 10.3389/fmed.2023.1096458. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37265481 Free PMC article. Review.
-
Effective immuno-therapeutic treatment of Canine Leishmaniasis.PLoS Negl Trop Dis. 2023 May 22;17(5):e0011360. doi: 10.1371/journal.pntd.0011360. eCollection 2023 May. PLoS Negl Trop Dis. 2023. PMID: 37216392 Free PMC article.
References
-
- Singh S. New developments in diagnosis of leishmaniasis. Indian J Med Res. 2006;123:311–30. - PubMed
-
- Singh N. Drug resistance mechanisms in clinical isolates of Leishmania donovani. Indian J Med Res. 2006;123:411–22. - PubMed
-
- Chappuis F, Sundar S, Hailu A, Ghalib H, Rijal S, Peeling RW, et al. Visceral leishmaniasis: What are the needs for diagnosis, treatment and control? Nat Rev Microbiol. 2007;5:873–82. - PubMed
-
- Sundar S, Jha TK, Thakur CP, Engel J, Sindermann H, Fischer C, et al. Oral miltefosine for Indian visceral leishmaniasis. N Engl J Med. 2002;347:1739–46. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources