Review
doi: 10.1016/0166-2236(89)90125-2.
Cholinergic and noradrenergic modulation of thalamocortical processing
- PMID: 2473557
- DOI: 10.1016/0166-2236(89)90125-2
Item in Clipboard
Review
Cholinergic and noradrenergic modulation of thalamocortical processing
Trends Neurosci.
1989 Jun.
Abstract
During periods of drowsiness and synchronized sleep, thalamocortical neuronal activity is dominated by rhythmic oscillations. The shift to waking and attentiveness is associated with an abolition of these rhythms and a marked increase in neuronal responsiveness to synaptic inputs. These shifts in thalamocortical processing are controlled by ascending modulatory neurotransmitter systems of which the cholinergic and noradrenergic components play a key role. By altering the amplitude of specialized potassium currents in thalamic and cortical neurons, acetylcholine and norepinephrine can block the generation of thalamocortical rhythms and promote a state of excitability that is consistent with cognition.
Comment in
-
Signal-to-noise in neuromodulation.Trends Neurosci. 1989 Dec;12(12):494. doi: 10.1016/0166-2236(89)90105-7. Trends Neurosci. 1989. PMID: 2480662 No abstract available.
Similar articles
-
Actions of norepinephrine in the cerebral cortex and thalamus: implications for function of the central noradrenergic system.Prog Brain Res. 1991;88:293-305. doi: 10.1016/s0079-6123(08)63817-0. Prog Brain Res. 1991. PMID: 1726028 Review.
-
Cholinergic blockage of network- and intrinsically generated slow oscillations promotes waking and REM sleep activity patterns in thalamic and cortical neurons.Prog Brain Res. 1993;98:345-55. doi: 10.1016/s0079-6123(08)62418-8. Prog Brain Res. 1993. PMID: 8248523 Review. No abstract available.
-
Sleep oscillations and their blockage by activating systems.J Psychiatry Neurosci. 1994 Nov;19(5):354-8. J Psychiatry Neurosci. 1994. PMID: 7803369 Free PMC article. Review.
-
Modulation of spindle oscillations by acetylcholine, cholecystokinin and 1S,3R-ACPD in the ferret lateral geniculate and perigeniculate nuclei in vitro.Neuroscience. 1997 Mar;77(2):335-50. doi: 10.1016/s0306-4522(96)00481-2. Neuroscience. 1997. PMID: 9472394
-
Acetylcholine systems and rhythmic activities during the waking--sleep cycle.Prog Brain Res. 2004;145:179-96. doi: 10.1016/S0079-6123(03)45013-9. Prog Brain Res. 2004. PMID: 14650916 Review.
Cited by
-
Prefrontal projections to the thalamic reticular nucleus form a unique circuit for attentional mechanisms.J Neurosci. 2006 Jul 12;26(28):7348-61. doi: 10.1523/JNEUROSCI.5511-05.2006. J Neurosci. 2006. PMID: 16837581 Free PMC article.
-
Reliable neuromodulation from circuits with variable underlying structure.Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11742-6. doi: 10.1073/pnas.0905614106. Epub 2009 Jun 24. Proc Natl Acad Sci U S A. 2009. PMID: 19553211 Free PMC article.
-
High frequency action potential bursts (>or= 100 Hz) in L2/3 and L5B thick tufted neurons in anaesthetized and awake rat primary somatosensory cortex.J Physiol. 2008 Jul 15;586(14):3353-64. doi: 10.1113/jphysiol.2008.155580. Epub 2008 May 15. J Physiol. 2008. PMID: 18483066 Free PMC article.
-
Decoding Circadian Rhythm and Epileptic Activities: Clues From Animal Studies.Front Neurol. 2020 Jul 24;11:751. doi: 10.3389/fneur.2020.00751. eCollection 2020. Front Neurol. 2020. PMID: 32793110 Free PMC article. Review.
-
Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making.Elife. 2023 Dec 1;12:RP87022. doi: 10.7554/eLife.87022. Elife. 2023. PMID: 38038722 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
