Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores
- PMID: 2469965
- DOI: 10.1038/339064a0
Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores
Abstract
The cross-linkage of high affinity Fc epsilon receptors (Fc epsilon RI) on mast cells and basophils is central to the induction of allergic inflammatory responses. As a result of such cross-linkage, mast cells secrete a variety of preformed biologically active substances, such as histamine, and newly synthesized arachidonic acid metabolites. Here we show that cross-linkage of Fc epsilon RI on a series of nontransformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2 cells). These factors include interleukin-3 (a mast cell growth factor)s interleukin-4 (an IgE 'switch factor'), interleukin-5 (an eosinophil differentiation factor) and interleukin-6 (a factor controlling immunoglobulin secretion). The production of these polypeptide factors by mast cells may have great importance in the induction of allergic and anti-parasite inflammatory responses.
Similar articles
-
Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production.Int Arch Allergy Immunol. 2010;152 Suppl 1:22-31. doi: 10.1159/000312122. Epub 2010 Jun 4. Int Arch Allergy Immunol. 2010. PMID: 20523060
-
Mast cell stimulation by monoclonal antibodies specific for the Fc epsilon receptor yields distinct responses of arachidonic acid and leukotriene C4 secretion.Eur J Immunol. 1989 Dec;19(12):2251-6. doi: 10.1002/eji.1830191211. Eur J Immunol. 1989. PMID: 2532599
-
Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.J Clin Invest. 1995 Feb;95(2):577-85. doi: 10.1172/JCI117701. J Clin Invest. 1995. PMID: 7860741 Free PMC article.
-
Interleukin-4 production by Fc epsilon R+ cells.Skin Pharmacol. 1991;4 Suppl 1:8-14. Skin Pharmacol. 1991. PMID: 1837220 Review.
-
Regulation of mast-cell and basophil function and survival by IgE.Nat Rev Immunol. 2002 Oct;2(10):773-86. doi: 10.1038/nri914. Nat Rev Immunol. 2002. PMID: 12360215 Review.
Cited by
-
Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome.J Clin Invest. 1990 May;85(5):1666-71. doi: 10.1172/JCI114618. J Clin Invest. 1990. PMID: 2110192 Free PMC article.
-
The Role of TRP Proteins in Mast Cells.Front Immunol. 2012 Jun 12;3:150. doi: 10.3389/fimmu.2012.00150. eCollection 2012. Front Immunol. 2012. PMID: 22701456 Free PMC article.
-
Murine mast cells synthesize basement membrane components. A potential role in early fibrosis.J Clin Invest. 1991 Feb;87(2):619-23. doi: 10.1172/JCI115038. J Clin Invest. 1991. PMID: 1991845 Free PMC article.
-
Recombinant herpes simplex virus type 1 expressing murine interleukin-4 is less virulent than wild-type virus in mice.J Virol. 2001 Oct;75(19):9029-36. doi: 10.1128/JVI.75.19.9029-9036.2001. J Virol. 2001. PMID: 11533166 Free PMC article.
-
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells.EMBO J. 2000 Oct 16;19(20):5387-95. doi: 10.1093/emboj/19.20.5387. EMBO J. 2000. PMID: 11032806 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
