Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jun;10(6):322-37.
doi: 10.1038/nrendo.2014.35. Epub 2014 Mar 25.

Autophagy--a key player in cellular and body metabolism

Kook Hwan Kim  1 , Myung-Shik Lee  1
Affiliations
Review

Autophagy--a key player in cellular and body metabolism

Kook Hwan Kim et al. Nat Rev Endocrinol. 2014 Jun.

Abstract

Knowledge gained over the past 10 years about the mechanisms that underpin autophagy has provided a universal framework for studies of diverse physiological and pathological processes. Of particular interest is the emerging role of autophagy in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. Dysregulation of autophagy might contribute to the development of metabolic disorders, including insulin resistance, diabetes mellitus, obesity, atherosclerosis and osteoporosis. The authors of this Review highlight research findings on the regulation of cellular autophagy by nutrients. They also describe the role of autophagy in various tissues in the regulation of energy metabolism and the development of diseases related to altered metabolism. Finally, the potential of pharmacological modulation of autophagy as a treatment for human metabolic disorders is discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Autophagy. 2012 Dec;8(12):1757-68 - PubMed
    1. J Biol Chem. 2011 Sep 16;286(37):32324-32 - PubMed
    1. Nature. 2008 Nov 13;456(7219):264-8 - PubMed
    1. Science. 2004 Oct 15;306(5695):457-61 - PubMed
    1. EMBO Rep. 2013 Sep;14(9):795-803 - PubMed