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Review
. 2014 Mar 17;25(3):304-17.
doi: 10.1016/j.ccr.2014.01.021.

Mutant p53 in cancer: new functions and therapeutic opportunities

Patricia A J Muller  1 , Karen H Vousden  2
Affiliations
Review

Mutant p53 in cancer: new functions and therapeutic opportunities

Patricia A J Muller et al. Cancer Cell. .

Abstract

Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.

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Figures

Figure 1
Figure 1
Strategies that Are Currently Being Explored to Target Mutant p53 Depicted in red are schematics of the strategies that are currently being explored to target p53 mutant-expressing cancers. These strategies include promotion of mutant p53 degradation through the proteasome and autophagy pathways, restoration of wild-type p53 activity, interference with the interaction between mutant p53 and other proteins, and interference in signaling pathways downstream of mutant p53.
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