Impact of human adenovirus serotype 7 in hospitalized children with severe fatal pneumonia in the Philippines
- PMID: 24647252
- DOI: 10.7883/yoken.67.105
Impact of human adenovirus serotype 7 in hospitalized children with severe fatal pneumonia in the Philippines
Abstract
Human adenovirus (HAdV) serotype 7 is an important etiological agent of severe childhood pneumonia. The aim of this study was to define the role of HAdV7 and to describe its clinical and molecular epidemiological characteristics in the Philippines in 2011. HAdVs were detected by viral culture, and a partial region of hexon gene was sequenced. A total of 700 patients were enrolled, of which 22 (3.1%) died. Nine (1.3%) HAdV cases were confirmed, of which 7 were positive for HAdV7, 1 for HAdV3, and 1 for HAdV5. Among the 9 HAdV-positive cases, 4 (44%) with HAdV7 died. Molecular analysis revealed that all HAdV7 isolates were closely related to genome type h strains. This study demonstrated the significance of HAdV7 as an etiological agent of severe pediatric pneumonia with a high fatality rate. Hence, continuous monitoring is required to define the clinical and public health significance of HAdV7 infection.
Similar articles
-
Molecular and serological characterization of species B2 adenovirus strains isolated from children hospitalized with acute respiratory disease in Buenos Aires, Argentina.J Clin Virol. 2013 Sep;58(1):4-10. doi: 10.1016/j.jcv.2013.06.030. Epub 2013 Jul 22. J Clin Virol. 2013. PMID: 23886503
-
Temporal changes in respiratory adenovirus serotypes circulating in the greater Toronto area, Ontario, during December 2008 to April 2010.Virol J. 2013 Jan 7;10:15. doi: 10.1186/1743-422X-10-15. Virol J. 2013. PMID: 23294909 Free PMC article.
-
Adenovirus Type 7 Pneumonia in Children Who Died from Measles-Associated Pneumonia, Hanoi, Vietnam, 2014.Emerg Infect Dis. 2016 Apr;22(4):687-90. doi: 10.3201/eid2204.151595. Emerg Infect Dis. 2016. PMID: 26926035 Free PMC article.
-
Human adenovirus type 8: the major agent of epidemic keratoconjunctivitis (EKC).J Clin Virol. 2014 Dec;61(4):477-86. doi: 10.1016/j.jcv.2014.10.015. Epub 2014 Nov 4. J Clin Virol. 2014. PMID: 25464969 Review.
-
Adenovirus infections in immunocompetent and immunocompromised patients.Clin Microbiol Rev. 2014 Jul;27(3):441-62. doi: 10.1128/CMR.00116-13. Clin Microbiol Rev. 2014. PMID: 24982316 Free PMC article. Review.
Cited by
-
A triplex quantitative real-time PCR assay for differential detection of human adenovirus serotypes 2, 3 and 7.Virol J. 2018 May 2;15(1):81. doi: 10.1186/s12985-018-0983-x. Virol J. 2018. PMID: 29716642 Free PMC article.
-
Incidence of lower respiratory tract infection and associated viruses in a birth cohort in the Philippines.BMC Infect Dis. 2022 Mar 30;22(1):313. doi: 10.1186/s12879-022-07289-3. BMC Infect Dis. 2022. PMID: 35354368 Free PMC article.
-
Human mastadenovirus-B (HAdV-B)-specific E3-CR1β and E3-CR1γ glycoproteins interact with each other and localize at the plasma membrane of non-polarized airway epithelial cells.Virology. 2020 Jul;546:67-78. doi: 10.1016/j.virol.2020.04.005. Epub 2020 Apr 15. Virology. 2020. PMID: 32452418 Free PMC article.
-
Clinical and molecular features of adenovirus type 2, 3, and 7 infections in children in an outbreak in Taiwan, 2011.Clin Microbiol Infect. 2017 Feb;23(2):110-116. doi: 10.1016/j.cmi.2016.11.004. Epub 2016 Nov 13. Clin Microbiol Infect. 2017. PMID: 27851998 Free PMC article.
-
A Single-Cycle Adenovirus Type 7 Vaccine for Prevention of Acute Respiratory Disease.Viruses. 2019 May 3;11(5):413. doi: 10.3390/v11050413. Viruses. 2019. PMID: 31058858 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
