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. 2014 Mar;62(3):417-25.
doi: 10.1111/jgs.12693. Epub 2014 Feb 27.

Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: the Concord Health and Ageing in Men Project

Vasant Hirani  1 , Robert G Cumming, Vasi Naganathan, Fiona Blyth, David G Le Couteur, David J Handelsman, Louise M Waite, Markus J Seibel
Affiliations

Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: the Concord Health and Ageing in Men Project

Vasant Hirani et al. J Am Geriatr Soc. 2014 Mar.

Abstract

Objectives: To explore associations between serum 25-hydroxyvitamin D (25(OH)D) levels and a wide range of health conditions, physical performance measures, disability, and mortality in a large epidemiological study to identify an optimum range for 25(OH)D concentrations.

Design: Cross-sectional study, with additional prospective data on falls and mortality.

Setting: Concord Health and Ageing in Men Project, Sydney, Australia.

Participants: Community-dwelling men aged 70 and older (N = 1,659).

Measurements: Serum 25(OH)D levels, general health status, self-reported diseases, physical performance measures, disability (activities of daily living and instrumental activities of daily living) and falls.

Results: Fair, poor, and very poor health; self-reported diabetes mellitus; hyperglycemia; depression; muscle weakness; poor balance; and all-cause mortality were all associated with serum 25(OH)D levels less than 50 nmol/L, even after adjustment for confounding. The findings also suggest that, in older men, for a wide range of health conditions, physical performance measures, disability, falls, and mortality, the optimum range of 25(OH)D is between 50.0 and 74.9 nmol/L, with no additional benefit for 25(OH)D levels of 75.0 nmol/L or greater.

Conclusion: Programs aimed at achieving an optimum range of serum 25(OH)D at levels between 50.0 and 74.9 nmol/L may have overall health benefits and such levels are adequate for older men.

Keywords: Australia; Sydney; health outcomes; older men; population study; vitamin D levels.

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