Traditional Chinese medicine and related active compounds: a review of their role on hepatitis B virus infection
- PMID: 24423652
- DOI: 10.5582/ddt.2013.v7.6.212
Traditional Chinese medicine and related active compounds: a review of their role on hepatitis B virus infection
Abstract
Since the significant public health hazard of Hepatitis B virus (HBV) infection and obvious drug resistance and dose-dependent side effects for common antiviral agents (e.g., interferon α, lamivudine, and adefovir), continuous development of agents to treat HBV infection is urgently needed. Traditional Chinese medicine (TCM) is an established segment of the health care system in China. Currently, it is widely used for chronic hepatitis B (CHB) in China and many parts of the world. Over a long period of time in clinical practice and in basic research progress, the effectiveness and beneficial contribution of TCM on CHB have been gradually known and confirmed. Based upon our review of related papers and because of our prior knowledge and experience, we have selected some Chinese medicines, including Chinese herbal formulas (e.g., Xiao-Chai-Hu-Tang, Xiao-Yao-San, and Long-Dan-Xie-Gan-Tang), single herbs (e.g., Phyllanthus niruri, Radix astragali, Polygonum cuspidatum, Rheum palmatum, and Salvia miltiorrhiza) and related active compounds (e.g., wogonin, artesunate, saikosaponin, astragaloside IV, and chrysophanol 8-O-beta-Dglucoside) and Chinese medicine preparations (e.g., silymarin, silibinin, kushenin, and cinobufacini), which seem effective and worthy of additional and indepth study in treating CHB, and we have given them a brief review. We conclude that these Chinese herbal medicines exhibit significant anti-HBV activities with improved liver function, and enhanced HBeAg and HBsAg sero-conversion rates as well as HBV DNA clearance rates in HepG2 2.2.15 cells, DHBV models, or patients with CHB. We hope this review will contribute to an understanding of TCM and related active compounds as an effective treatment for CHB and provide useful information for the development of more effective antiviral drugs.
Similar articles
-
Traditional Chinese medicine and related active compounds against hepatitis B virus infection.Biosci Trends. 2010 Apr;4(2):39-47. Biosci Trends. 2010. PMID: 20448340 Review.
-
Anti-HBV effect of individual traditional Chinese herbal medicine in vitro and in vivo: an analytic review.J Viral Hepat. 2013 Jul;20(7):445-52. doi: 10.1111/jvh.12112. J Viral Hepat. 2013. PMID: 23730837 Review.
-
Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review.Hepatology. 2010 Feb;51(2):690-8. doi: 10.1002/hep.23384. Hepatology. 2010. PMID: 20101751 Free PMC article. Review.
-
Review article: Herbal hepatotoxicity--an update on traditional Chinese medicine preparations.Aliment Pharmacol Ther. 2014 Jul;40(1):32-50. doi: 10.1111/apt.12798. Epub 2014 May 20. Aliment Pharmacol Ther. 2014. PMID: 24844799 Review.
-
Phyllanthus species versus antiviral drugs for chronic hepatitis B virus infection.Cochrane Database Syst Rev. 2013 Apr 30;(4):CD009004. doi: 10.1002/14651858.CD009004.pub2. Cochrane Database Syst Rev. 2013. PMID: 23633363 Review.
Cited by
-
Network analysis and experimental verification of Salvia miltiorrhiza Bunge-Reynoutria japonica Houtt. drug pair in the treatment of non-alcoholic fatty liver disease.BMC Complement Med Ther. 2024 Aug 14;24(1):305. doi: 10.1186/s12906-024-04600-4. BMC Complement Med Ther. 2024. PMID: 39143459 Free PMC article.
-
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.Chin Med. 2024 Mar 18;19(1):48. doi: 10.1186/s13020-024-00888-z. Chin Med. 2024. PMID: 38500179 Free PMC article.
-
Herbalism and glass-based materials in dentistry: review of the current state of the art.J Mater Sci Mater Med. 2023 Nov 14;34(11):60. doi: 10.1007/s10856-023-06764-w. J Mater Sci Mater Med. 2023. PMID: 37962680 Free PMC article. Review.
-
Astersaponin I from Aster koraiensis is a natural viral fusion blocker that inhibits the infection of SARS-CoV-2 variants and syncytium formation.Antiviral Res. 2022 Dec;208:105428. doi: 10.1016/j.antiviral.2022.105428. Epub 2022 Oct 15. Antiviral Res. 2022. PMID: 36252824 Free PMC article.
-
Antitumor effects of Chinese herbal medicine compounds and their nano-formulations on regulating the immune system microenvironment.Front Oncol. 2022 Sep 23;12:949332. doi: 10.3389/fonc.2022.949332. eCollection 2022. Front Oncol. 2022. PMID: 36212483 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous