doi: 10.1128/JVI.61.8.2639-2641.1987.
Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus
- PMID: 2439707
- PMCID: PMC255715
- DOI: 10.1128/JVI.61.8.2639-2641.1987
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Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus
J Virol.
1987 Aug.
Abstract
Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid sequence (amino acids 603-609) containing two cysteine residues. Both cysteine residues are required for the antigenic conformation of the sequence, possibly due to creation of a cyclic structure via disulfide bond formation.
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