doi: 10.1038/323036a0.
Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel
- PMID: 2427958
- DOI: 10.1038/323036a0
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Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel
Nature.
1986 Sep.
Abstract
Osmotic stress can be used to estimate the internal volume change during the opening and closing of a voltage gated ionic channel. Mitochondrial voltage-dependent anion channels, from rat liver and from Neurospora, reconstituted into planar lipid bilayers show a change of 2 to 4 X 10(4) A3 in internal volume, a large change inconsistent with a blocking or local gating model but supporting models with major closure of the channel space.
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