The endoplasmic reticulum-mitochondria connection: one touch, multiple functions
- PMID: 24211533
- DOI: 10.1016/j.bbabio.2013.10.015
The endoplasmic reticulum-mitochondria connection: one touch, multiple functions
Abstract
The endoplasmic reticulum (ER) and mitochondria are tubular organelles with a characteristic "network structure" that facilitates the formation of interorganellar connections. The ER and mitochondria join together at multiple contact sites to form specific domains, termed mitochondria-ER associated membranes (MAMs), with distinct biochemical properties and a characteristic set of proteins. The functions of these two organelles are coordinated and executed at the ER-mitochondria interface, which provides a platform for the regulation of different processes. The roles played by the ER-mitochondria interface range from the coordination of calcium transfer to the regulation of mitochondrial fission and inflammasome formation as well as the provision of membranes for autophagy. The novel and unconventional processes that occur at the ER-mitochondria interface demonstrate its multifunctional and intrinsically dynamic nature. This article is part of a Special Issue entitled: Dynamic and ultrastructure of bioenergetic membranes and their components.
Keywords: Autophagy; Calcium; Endoplasmic reticulum; Inflammation; MAM; mitochondria.
Copyright © 2013 Elsevier B.V. All rights reserved.
Similar articles
-
Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM).Biochim Biophys Acta. 2013 Jan;1833(1):213-24. doi: 10.1016/j.bbamcr.2012.04.013. Epub 2012 May 2. Biochim Biophys Acta. 2013. PMID: 22575682 Review.
-
New functions of mitochondria associated membranes in cellular signaling.Biochim Biophys Acta. 2014 Oct;1843(10):2253-62. doi: 10.1016/j.bbamcr.2014.03.009. Epub 2014 Mar 15. Biochim Biophys Acta. 2014. PMID: 24642268 Review.
-
Mechanistic Connections between Endoplasmic Reticulum (ER) Redox Control and Mitochondrial Metabolism.Cells. 2019 Sep 12;8(9):1071. doi: 10.3390/cells8091071. Cells. 2019. PMID: 31547228 Free PMC article. Review.
-
The roles of mitochondria-associated membranes in mitochondrial quality control under endoplasmic reticulum stress.Life Sci. 2019 Aug 15;231:116587. doi: 10.1016/j.lfs.2019.116587. Epub 2019 Jun 18. Life Sci. 2019. PMID: 31220526 Review.
-
Mitochondria Associated Membranes (MAMs): Architecture and physiopathological role.Cell Calcium. 2021 Mar;94:102343. doi: 10.1016/j.ceca.2020.102343. Epub 2021 Jan 2. Cell Calcium. 2021. PMID: 33418313 Review.
Cited by
-
P2X7 Receptor and Purinergic Signaling: Orchestrating Mitochondrial Dysfunction in Neurodegenerative Diseases.eNeuro. 2022 Nov 14;9(6):ENEURO.0092-22.2022. doi: 10.1523/ENEURO.0092-22.2022. Print 2022 Nov-Dec. eNeuro. 2022. PMID: 36376084 Free PMC article. Review.
-
From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson's Disease: Lessons From LRRK2.Front Cell Neurosci. 2020 Jul 28;14:158. doi: 10.3389/fncel.2020.00158. eCollection 2020. Front Cell Neurosci. 2020. PMID: 32848606 Free PMC article. Review.
-
Automatic Reconstruction of Mitochondria and Endoplasmic Reticulum in Electron Microscopy Volumes by Deep Learning.Front Neurosci. 2020 Jul 21;14:599. doi: 10.3389/fnins.2020.00599. eCollection 2020. Front Neurosci. 2020. PMID: 32792893 Free PMC article.
-
MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response.EMBO J. 2024 Feb;43(3):339-361. doi: 10.1038/s44318-024-00029-0. Epub 2024 Jan 18. EMBO J. 2024. PMID: 38238476 Free PMC article.
-
Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.Biochem Biophys Res Commun. 2018 Nov 30;506(3):463-470. doi: 10.1016/j.bbrc.2018.10.073. Epub 2018 Oct 22. Biochem Biophys Res Commun. 2018. PMID: 30352685 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
