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. 2013 Nov;19(11):1819-23.
doi: 10.3201/eid1911.131172.

Middle East respiratory syndrome coronavirus in bats, Saudi Arabia

Ziad A Memish, Nischay Mishra, Kevin J Olival, Shamsudeen F Fagbo, Vishal Kapoor, Jonathan H Epstein, Rafat Alhakeem, Abdulkareem Durosinloun, Mushabab Al Asmari, Ariful Islam, Amit Kapoor, Thomas Briese, Peter Daszak, Abdullah A Al Rabeeah, W Ian Lipkin

Middle East respiratory syndrome coronavirus in bats, Saudi Arabia

Ziad A Memish et al. Emerg Infect Dis. 2013 Nov.

Abstract

The source of human infection with Middle East respiratory syndrome coronavirus remains unknown. Molecular investigation indicated that bats in Saudi Arabia are infected with several alphacoronaviruses and betacoronaviruses. Virus from 1 bat showed 100% nucleotide identity to virus from the human index case-patient. Bats might play a role in human infection.

Keywords: MERS CoV; Middle East respiratory syndrome; Saudi Arabia; bats; coronavirus; viruses.

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Figures

Figure 1
Figure 1
Bat sampling sites and locations of home and workplace of index case-patient with Middle East respiratory syndrome, Bisha, Saudi Arabia.
Figure 2
Figure 2
Phylogenetic tree showing genetic relatedness between coronaviruses identified in bat samples from Saudi Arabia (boldface), MERS coronaviruses, and other published coronavirus sequences available in GenBank. The maximum-likelihood tree of partial RNA-dependent RNA polymerase gene (nt position 15068–15249 of GenBank accession no. JX869059) was constructed by using the Tamura-Nei model with discrete gamma rate differences among sites as implemented in MEGA 5.2 (www.megasoftware.net). Each branch shows the GenBank accession number followed by a brief description of the sequence used. Scale bar indicates nucleotide substitutions per site. MERS, Middle East respiratory syndrome; CoV, coronavirus; SARS, severe acute respiratory syndrome; KSA, Kingdom of Saudi Arabia.
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References

    1. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367:1814–20 . 10.1056/NEJMoa1211721 - DOI - PubMed
    1. Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DA, et al. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med. 2013;369:407–16. 10.1056/NEJMoa1306742 - DOI - PMC - PubMed
    1. Annan A, Baldwin HJ, Corman VM, Klose SM, Owusu M, Nkrumah EE, et al. Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe. Emerg Infect Dis. 2013;19:456–9. 10.3201/eid1903.121503 - DOI - PMC - PubMed
    1. Anthony SJ, Ojeda-Flores R, Rico-Chavez O, Navarrete-Macias I, Zambrana-Torrelio CM, Rostal MK, et al. Coronaviruses in bats from Mexico. J Gen Virol. 2013;94:1028–38. 10.1099/vir.0.049759-0 - DOI - PMC - PubMed
    1. Ithlete NL, Stoffberg S, Corman VM, Cottontail VM, Richards LR, Schoeman MC, et al. Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa [letter]. Emerg Infect Dis. 2013:19 [cited 2013 Aug 19]. http://wwwnc.cdc.gov/eid/article/19/10/13-0946_article.htm - PMC - PubMed

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