Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014;21(3):261-9.
doi: 10.2174/09298673113206660303.

An update on autoinflammatory diseases

F Ciccarelli, M De Martinis, L Ginaldi  1
Affiliations
Free PMC article

An update on autoinflammatory diseases

F Ciccarelli et al. Curr Med Chem. 2014.
Free PMC article

Abstract

Autoinflammatory diseases area group of clinical conditions other than autoimmune diseases, characterized by recurrent inflammatory episodes. From apathogenetic point of view they are determined by a dys regulation of innate immunity, without involvement of specific immunity (auto reactive T cells and auto antibodies). Recently, the increased knowledge in the field of auto inflammation highlighted shared immune mechanisms in the pathogenesis of both classical monogenetic and multifactorial auto inflammatory diseases and a broad spectrum of chronic age-related inflammatory pathologies. The current increase in the prevalence of chronic inflammatory diseases makes this subject of topical interest. In the light of these considerations, we propose an update of auto inflammatory diseases and a new interpretation of auto inflammation with both theoretical and clinical implications.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. McDermott MF, Aksentijevich I, Galon J, McDermott EM, Ogunkolade BW, Centola M, Mansfield E, Gadina M, Karenko L, Pettersson T, McCarthy J, Frucht DM, Aringer M, Torosyan Y, Teppo AM, Wilson M, Karaarslan HM, Wan Y, Todd I, Wood G, Schlimgen R, Kumarajeewa TR, Cooper SM, Vella JP, Amos CI, Mulley J, Quane KA, Molloy MG, Ranki A, Powell RJ, Hitman GA, O'Shea JJ, Kastner DL. Germline mutations in the extracellular domains of the 55 kDa TNF receptor TNFR1 define a family of dominantly inherited autoinflammatory syndromes. Cell. 1999;97(1):133–144. - PubMed
    1. Ginaldi L, DiBenedetto MC, DeMartinis M. Osteoporosis inflammation and ageing. Immun. Ageing. 2005;2:14. - PMC - PubMed
    1. Franceschi C, Bonafe M, Valensin S, Olivieri F, DeLuca M, Ottaviani E, DeBenedictis G. Inflammaging.An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. USA. 2000;908:244–254. - PubMed
    1. Salminen A, Kaarniranta K, Kauppinen A. Inflammaging disturbed interplay between autophagy and inflammasomes. Aging. 2012;4(3):166–175. - PMC - PubMed
    1. Folashade AJ, Melvin BH. Extraintestinal manifestations of Inflammatory Bowel Disease. J. Pediatr. Gastroenterol. Nutr. 2008;46(2):124–133. - PMC - PubMed