IntOGen-mutations identifies cancer drivers across tumor types

doi:10.1038/nmeth.2642

. 2013 Nov;10(11):1081-2.

doi: 10.1038/nmeth.2642. Epub 2013 Sep 15.

IntOGen-mutations identifies cancer drivers across tumor types

Abel Gonzalez-Perez¹, Christian Perez-Llamas, Jordi Deu-Pons, David Tamborero, Michael P Schroeder, Alba Jene-Sanz, Alberto Santos, Nuria Lopez-Bigas

Affiliations

PMID: 24037244
PMCID: PMC5758042
DOI: 10.1038/nmeth.2642

IntOGen-mutations identifies cancer drivers across tumor types

Abel Gonzalez-Perez et al. Nat Methods. 2013 Nov.

. 2013 Nov;10(11):1081-2.

doi: 10.1038/nmeth.2642. Epub 2013 Sep 15.

Authors

Abel Gonzalez-Perez¹, Christian Perez-Llamas, Jordi Deu-Pons, David Tamborero, Michael P Schroeder, Alba Jene-Sanz, Alberto Santos, Nuria Lopez-Bigas

Affiliation

¹ Research Unit on Biomedical Informatics, Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain.

PMID: 24037244
PMCID: PMC5758042
DOI: 10.1038/nmeth.2642

Abstract

The IntOGen-mutations platform (http://www.intogen.org/mutations/) summarizes somatic mutations, genes and pathways involved in tumorigenesis. It identifies and visualizes cancer drivers, analyzing 4,623 exomes from 13 cancer sites. It provides support to cancer researchers, aids the identification of drivers across tumor cohorts and helps rank mutations for better clinical decision-making.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

**Figure 1**
Schematic representation of the analysis performed by the IntOGen-mutations analysis pipeline.

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References

1. The International Cancer Genome Consortium. Nature464, 993–998 (2010). - PubMed
1. Weinstein, J.N. et al. Nat. Genetics 10.1038/ng.2764 (in the press).
1. Zhang J, et al. Database (Oxford) 2011;2011:bar026. - PMC - PubMed
1. Cerami E, et al. Cancer Discov. 2012;2:401–404. doi: 10.1158/2159-8290.CD-12-0095. - DOI - PMC - PubMed
1. Forbes SA, et al. Nucleic Acids Res. 2010;38:D652–D657. doi: 10.1093/nar/gkp995. - DOI - PMC - PubMed

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[1] The International Cancer Genome Consortium. Nature464, 993–998 (2010). - PubMed

[2] The International Cancer Genome Consortium. Nature464, 993–998 (2010). - PubMed

[3] Weinstein, J.N. et al. Nat. Genetics 10.1038/ng.2764 (in the press).

[4] Weinstein, J.N. et al. Nat. Genetics 10.1038/ng.2764 (in the press).

[5] Zhang J, et al. Database (Oxford) 2011;2011:bar026. - PMC - PubMed

[6] Zhang J, et al. Database (Oxford) 2011;2011:bar026. - PMC - PubMed

[7] Cerami E, et al. Cancer Discov. 2012;2:401–404. doi: 10.1158/2159-8290.CD-12-0095. - DOI - PMC - PubMed

[8] Cerami E, et al. Cancer Discov. 2012;2:401–404. doi: 10.1158/2159-8290.CD-12-0095. - DOI - PMC - PubMed

[9] Forbes SA, et al. Nucleic Acids Res. 2010;38:D652–D657. doi: 10.1093/nar/gkp995. - DOI - PMC - PubMed

[10] Forbes SA, et al. Nucleic Acids Res. 2010;38:D652–D657. doi: 10.1093/nar/gkp995. - DOI - PMC - PubMed

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IntOGen-mutations identifies cancer drivers across tumor types

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IntOGen-mutations identifies cancer drivers across tumor types

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