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Review
. 2013 Nov;62(5):810-7.
doi: 10.1161/HYPERTENSIONAHA.113.01063. Epub 2013 Aug 26.

Hypertension: a harbinger of stroke and dementia

Giuseppe Faraco  1 , Costantino Iadecola
Affiliations
Review

Hypertension: a harbinger of stroke and dementia

Giuseppe Faraco et al. Hypertension. 2013 Nov.
No abstract available

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Conflict of interest statement

Conflicts of interest

None

Figures

Figure 1
Figure 1. Effect of HTN on cerebral blood vessels
HTN induces profound alterations of critical regulatory mechanisms of the cerebral circulation, which, in concert with the structural alterations, compromise the blood supply to the brain and increase the risk for stroke and dementia.
Figure 2
Figure 2. Ischemic brain lesions associated with HTN
HTN induces atherosclerosis of major extracranial and intracranial arteries which could lead to major infarcts. HTN causes both micro and macrobleeds and is the main pathogenetic factor for small vessel disease responsible for lacunar infarcts, white matter lesions (leukoaraiosis) and microinfarcts.
Figure 3
Figure 3. Interaction between HTN and AD
HTN increases the deposition of Aβ and might aggravate the cerebrovascular dysfunction induced by Aβ. HTN could impair the vascular clearance of Aβ and increase its cleavage from the amyloid precursor protein (APP). Both of these effects would lead to increased Aβ concentration in the brain parenchyma and blood vessels, aggravating the attendant vascular and synaptic dysfunction.
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