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. 2014 Feb 1;209(3):452-6.
doi: 10.1093/infdis/jit434. Epub 2013 Aug 20.

Virologic correlates of anti-CMV IgG levels in HIV-1-infected men

Sara Gianella  1 , Sheldon R Morris, Erick Tatro, Milenka V Vargas, Richard H Haubrich, Eric S Daar, Michael P Dube, Douglas D Richman, Susan J Little, Davey M Smith
Affiliations

Virologic correlates of anti-CMV IgG levels in HIV-1-infected men

Sara Gianella et al. J Infect Dis. .

Abstract

In human immunodeficiency virus (HIV)-infected individuals, higher levels of anti-cytomegalovirus (CMV) immunoglobulin G (IgG) antibody have been associated with increased immune activation, increased HIV transmission, cardiovascular complications, and neurocognitive impairment. However, the mechanism of these observations is unknown. This analysis of 228 HIV-infected men found that higher CMV IgG levels were positively associated with older age and antiretroviral treatment. Higher frequency of detectable CMV in peripheral blood mononuclear cells and recurrent seminal CMV reactivations were associated with lower plasma CMV IgG levels, suggesting that immune response to CMV rather than direct effect of viral replication is likely responsible for adverse clinical outcome observed in other studies.

Keywords: CMV IgG; CMV replication; HIV infection; immune response.

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Figures

Figure 1.
Figure 1.
Anti-cytomegalovirus (CMV) immunoglobulin G (IgG) levels in subjects with frequent and less-frequent CMV seminal shedding. CMV IgG levels were determined in blood plasma for 58 patients for whom longitudinal samples were available. Patients were divided into the following 2 groups: those with detectable seminal CMV DNA in <50% of visits (gray bars) and those with seminal shedding in ≥50% visits (black bars). X-axis indicates number of longitudinal visits, and y-axis indicates CMV IgG levels (UI/mL). Mean and 95% confidence interval are plotted. At both ≥3 and ≥4 visits, there was significantly more CMV IgG in the less-frequent seminal shedding group, as determined by Student t test (P < .01). *shows a trend; **shows significant P values.
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