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. 2013:2013:436727.
doi: 10.1155/2013/436727. Epub 2013 Jul 16.

The Clinical Correlations of Helicobacter pylori Virulence Factors and Chronic Spontaneous Urticaria

Yi-Chun Chiu  1 , Wei-Chen Tai, Seng-Kee Chuah, Ping-I Hsu, Deng-Chyang Wu, Keng-Liang Wu, Chao-Cheng Huang, Ji-Chen Ho, Johannes Ring, Wen-Chieh Chen
Affiliations

The Clinical Correlations of Helicobacter pylori Virulence Factors and Chronic Spontaneous Urticaria

Yi-Chun Chiu et al. Gastroenterol Res Pract. 2013.

Abstract

Background and Study Aims. The association between Helicobacter pylori (H. pylori) and chronic spontaneous urticaria (CSU) remains controversial. This study explored the role of H. pylori in CSU among different virulent genotypes patients. Patients and Methods. Patients infected by H. pylori were sorted into two groups as group A (with CSU) and group B (without CSU). The tissue materials were taken via endoscopy for polymerase chain reaction study to determine virulence factors. After H. pylori eradication therapy, the eradication rate and response of urticaria were evaluated by using C(13)-UBT and a three-point scale (complete remission, partial remission, or no improvement). Results. The results were comparable between patients of groups A and B in terms of H. pylori infection rates and eradication rate. Longitudinal follow-up of 23.5 months showed complete remission of urticaria in 63.6% but no improvement in 36.4% of the patients after H. pylori eradication. H. pylori infected patients with different virulence factors such as cytotoxin-associated gene A, vacuolating cytotoxin gene A signal region and middle region have similar remission rates for CSU. Conclusions. Current study suggests that H. pylori may play a role in the development and disease course of CSU but may be irrelevant to different virulent genotypes.

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Figures

Figure 1
Figure 1
Allocation diagrams of patients with chronic spontaneous urticarial.
Figure 2
Figure 2
Results of PCR study showed the amplification products of Helicobacter-specific virulence factors cagA (324 bp), vacA s1 (259 bp), vacA s2 (286 bp), vacA m1 (290 bp), and vacA m2 (352 bp) such as patient 1 with CSU and positive genotypes cagA and vacA s1m1 and patient 2 (control group) with positive expression of cagA and vacA s1m2 but without CSU.
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References

    1. Ring J. Allergy in Practice. Berlin, Germany: Springer; 2005.
    1. Zuberbier T, Asero R, Bindslev-Jensen C, et al. EAACI/GA2LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria. Allergy. 2009;64(10):1417–1426. - PubMed
    1. Nichols KM, Cook-Bolden FE. Allergic skin disease: major highlights and recent advances. Medical Clinics of North America. 2009;93(6):1211–1224. - PubMed
    1. Philpott H, Kette F, Hissaria P, Gillis D, Smith W. Chronic urticaria: the autoimmune paradigm. Internal Medicine Journal. 2008;38(11):852–857. - PubMed
    1. Konturek SJ, Konturek PC, Konturek JW, et al. Helicobacter pylori and its involvement in gastritis and peptic ulcer formation. Journal of Physiology and Pharmacology. 2006;57(supplement 3):29–50. - PubMed

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