Review
doi: 10.1146/annurev-genom-091212-153515.
Epub 2013 Jul 15.
The spatial organization of the human genome
Affiliations
- PMID: 23875797
- DOI: 10.1146/annurev-genom-091212-153515
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Review
The spatial organization of the human genome
Annu Rev Genomics Hum Genet.
2013.
Abstract
In vivo, the human genome functions as a complex, folded, three-dimensional chromatin polymer. Understanding how the human genome is spatially organized and folded inside the cell nucleus is therefore central to understanding how genes are regulated in normal development and dysregulated in disease. Established light microscopy-based approaches and more recent molecular chromosome conformation capture methods are now combining to give us unprecedented insight into this fascinating aspect of human genomics.
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