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. 1990 Aug 20;269(1):15-8.
doi: 10.1016/0014-5793(90)81107-y.

Rates of cholesterol, ubiquinone, dolichol and dolichyl-P biosynthesis in rat brain slices

M Andersson  1 , P G Elmberger, C Edlund, K Kristensson, G Dallner
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Free article

Rates of cholesterol, ubiquinone, dolichol and dolichyl-P biosynthesis in rat brain slices

M Andersson et al. FEBS Lett. .
Free article

Abstract

Slices from the brain and liver of rats were prepared and upon incubation exhibited a continuous and high capacity for incorporation of radioactive precursors into proteins and lipids. Using [3H]mevalonate as precursor, the rates of biosynthesis of cholesterol, ubiquinone, dolichol and dolichyl-P in brain slices were determined and found to be 5.5, 0.25, 0.0093 and 0.0091 nmol/h/g, respectively. Dolichol and dolichyl-P accumulate to a limited extent, but almost all of these lipids in the brain originate from de novo synthesis. The calculated half-lives for cholesterol, ubiquinone, dolichol and dolichyl-P were 4076, 90, 1006 and 171 h, respectively. The results indicate that lipids formed via the mevalonate pathway in the brain have an active and independently regulated biosynthesis.

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