Review
doi: 10.1111/exd.12163.
TRPV3: a 'more than skinny' channel
Affiliations
- PMID: 23800054
- DOI: 10.1111/exd.12163
Item in Clipboard
Review
TRPV3: a 'more than skinny' channel
Exp Dermatol.
2013 Jul.
Abstract
The skin is our largest organ serving different tasks from barrier formation through somatosensing to hair development. Recently, members of the large trp (Transient Receptor Potential, TRP) gene family encoding proteins that form cation selective ion channel have been identified to play a crucial role in skin functions. Within the 28 different mammalian TRP channels, TRPV3 might be the most important member in the skin. This review gives an overview on functional properties of TRPV3 in skin physiology and in certain skin diseases.
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Similar articles
-
The Ca2+-Permeable Cation Transient Receptor Potential TRPV3 Channel: An Emerging Pivotal Target for Itch and Skin Diseases.Mol Pharmacol. 2017 Sep;92(3):193-200. doi: 10.1124/mol.116.107946. Epub 2017 Apr 4. Mol Pharmacol. 2017. PMID: 28377424 Review.
-
TRPV3: time to decipher a poorly understood family member!J Physiol. 2014 Jan 15;592(2):295-304. doi: 10.1113/jphysiol.2013.255968. Epub 2013 Jul 8. J Physiol. 2014. PMID: 23836684 Free PMC article. Review.
-
Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin.Biomolecules. 2023 Mar 10;13(3):513. doi: 10.3390/biom13030513. Biomolecules. 2023. PMID: 36979447 Free PMC article. Review.
-
TRPV3 Ion Channel: From Gene to Pharmacology.Int J Mol Sci. 2023 May 11;24(10):8601. doi: 10.3390/ijms24108601. Int J Mol Sci. 2023. PMID: 37239947 Free PMC article. Review.
-
Functional expression of transient receptor potential vanilloid 3 (TRPV3) in corneal epithelial cells: involvement in thermosensation and wound healing.Exp Eye Res. 2010 Jan;90(1):121-9. doi: 10.1016/j.exer.2009.09.020. Epub 2009 Sep 28. Exp Eye Res. 2010. PMID: 19793539
Cited by
-
Olmsted syndrome: clinical, molecular and therapeutic aspects.Orphanet J Rare Dis. 2015 Mar 17;10:33. doi: 10.1186/s13023-015-0246-5. Orphanet J Rare Dis. 2015. PMID: 25886873 Free PMC article. Review.
-
Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes.Int J Mol Sci. 2023 Aug 18;24(16):12930. doi: 10.3390/ijms241612930. Int J Mol Sci. 2023. PMID: 37629111 Free PMC article.
-
Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.J Biol Chem. 2016 May 6;291(19):10252-62. doi: 10.1074/jbc.M116.716464. Epub 2016 Mar 9. J Biol Chem. 2016. PMID: 26961876 Free PMC article.
-
The human transient receptor potential vanilloid 3 channel is sensitized via the ERK pathway.J Biol Chem. 2017 Dec 22;292(51):21083-21091. doi: 10.1074/jbc.M117.801167. Epub 2017 Oct 30. J Biol Chem. 2017. PMID: 29084846 Free PMC article.
-
Selenium and Neurological Diseases: Focus on Peripheral Pain and TRP Channels.Curr Neuropharmacol. 2020;18(6):501-517. doi: 10.2174/1570159X18666200106152631. Curr Neuropharmacol. 2020. PMID: 31903884 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
