The hallmarks of aging
- PMID: 23746838
- PMCID: PMC3836174
- DOI: 10.1016/j.cell.2013.05.039
The hallmarks of aging
Abstract
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contributions to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging, with minimal side effects.
Copyright © 2013 Elsevier Inc. All rights reserved.
Figures
Comment in
-
Prelamin A and Oct-1: a puzzle of aging.Oncotarget. 2015 Feb 28;6(6):3475-6. doi: 10.18632/oncotarget.3422. Oncotarget. 2015. PMID: 25708685 Free PMC article. No abstract available.
Similar articles
-
Hallmarks of aging: An expanding universe.Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3. Cell. 2023. PMID: 36599349 Review.
-
Mechanistic links between aging and lung fibrosis.Biogerontology. 2013 Dec;14(6):609-15. doi: 10.1007/s10522-013-9451-6. Epub 2013 Aug 9. Biogerontology. 2013. PMID: 23929205 Free PMC article. Review.
-
A revisiting of "the hallmarks of aging" in domestic dogs: current status of the literature.Geroscience. 2024 Feb;46(1):241-255. doi: 10.1007/s11357-023-00911-5. Epub 2023 Aug 18. Geroscience. 2024. PMID: 37594598 Free PMC article. Review.
-
The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging.J Bone Miner Res. 2018 Sep;33(9):1568-1584. doi: 10.1002/jbmr.3564. Epub 2018 Aug 13. J Bone Miner Res. 2018. PMID: 30075061 Free PMC article. Review.
-
Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging.Aging (Albany NY). 2014 Dec;6(12):992-1009. doi: 10.18632/aging.100710. Aging (Albany NY). 2014. PMID: 25543668 Free PMC article. Review.
Cited by
-
Associations of healthy eating patterns with biological aging: national health and nutrition examination survey (NHANES) 1999-2018.Nutr J. 2024 Sep 28;23(1):112. doi: 10.1186/s12937-024-01017-0. Nutr J. 2024. PMID: 39342289
-
p21 Regulates Wnt-Notch balance via DREAM/MMB/Rb-E2F1 and maintains intestinal stem cell homeostasis.Cell Death Discov. 2024 Sep 28;10(1):413. doi: 10.1038/s41420-024-02192-z. Cell Death Discov. 2024. PMID: 39341834
-
A Flow Cytometry-Based Examination of the Mouse White Blood Cell Differential in the Context of Age and Sex.Cells. 2024 Sep 20;13(18):1583. doi: 10.3390/cells13181583. Cells. 2024. PMID: 39329764 Free PMC article.
-
Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer's disease research.Elife. 2024 Sep 27;13:e90633. doi: 10.7554/eLife.90633. Elife. 2024. PMID: 39329365 Free PMC article. Review.
-
Chronic pain in the elderly: Exploring cellular and molecular mechanisms and therapeutic perspectives.Front Aging. 2024 Sep 12;5:1477017. doi: 10.3389/fragi.2024.1477017. eCollection 2024. Front Aging. 2024. PMID: 39328834 Free PMC article. Review.
References
-
- Ahlqvist KJ, Hamalainen RH, Yatsuga S, Uutela M, Terzioglu M, Gotz A, Forsstrom S, Salven P, Angers-Loustau A, Kopra OH, et al. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metab. 2012;15:100–109. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical