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Meta-Analysis
. 2013 May 22;8(5):e64851.
doi: 10.1371/journal.pone.0064851. Print 2013.

XRCC1 gene polymorphisms and the risk of differentiated thyroid carcinoma (DTC): a meta-analysis of case-control studies

Yi Bao  1 , Lei Jiang, Jue-Yu Zhou, Jun-Jie Zou, Jiao-Yang Zheng, Xiang-Fang Chen, Zhi-Min Liu, Yong-Quan Shi
Affiliations
Meta-Analysis

XRCC1 gene polymorphisms and the risk of differentiated thyroid carcinoma (DTC): a meta-analysis of case-control studies

Yi Bao et al. PLoS One. .

Abstract

Background: Previous studies investigating the association between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and thyroid cancer risk have yielded inconsistent results. This meta-analysis was performed to derive a more precise estimation of the relationship between three XRCC1 polymorphisms and thyroid cancer risk.

Methods/principal findings: PubMed and EMBASE database were systematically searched to identify relevant studies. 10 publications were selected for this meta-analysis, including 11 studies for Arg399Gln polymorphism (1726 cases and 3774 controls), 7 studies for Arg194Trp polymorphism (1037 cases and 2487 controls) and 8 studies for Arg280His polymorphism (1432 cases and 3356 controls). The results in total population did not show any significant association between these three polymorphisms and the risk of DTC for all genetic models. However, when stratified by ethnicity, the results showed that Arg280His polymorphism was associated with an increased risk of DTC among Caucasians (Arg/His vs. Arg/Arg: OR = 1.45, 95% CI = 1.09-1.93; dominant model: OR = 1.43, 95% CI = 1.08-1.89; additive model: OR = 1.38, 95% CI = 1.05-1.80), whereas individuals carrying Arg/His genotype have a significantly reduced risk of DTC among Asians (Arg/His vs. Arg/Arg: OR = 0.71, 95% CI = 0.51-0.98). We also detected that 399Gln variant allele carriers might presented an overall decreased risk of DTC in mixed population. Furthermore, subgroup analyses by histological subtype revealed that Arg194Trp polymorphism was significantly associated with reduced risk for papillary thyroid carcinoma (PTC) (dominant model: OR = 0.71, 95% CI = 0.50-0.99).

Conclusions: This meta-analysis suggests that Arg280His polymorphism might contribute to the susceptibility of DTC among Caucasians, whereas it might provide protective effects in Asians against the risk of DTC. Additionally, our results support the protective role of Arg194Trp polymorphism in developing PTC, and show evidence of an association between Arg399Gln polymorphism and decreased risk of DTC in mixed population.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow diagram of included studies for this meta-analysis.
Figure 2
Figure 2. Forest plots of ORs with 95% CI for XRCC1 Arg280His polymorphism and the risk of DTC observed in subgroup analyses by ethnicity (fixed effects).
The center of each square represents the OR, the area of the square is the number of sample and thus the weight used in the meta-analysis, and the horizontal line indicates the 95%CI. (A) Arg/His vs. Arg/Arg. (B) Dominant model. (C) Additive model.
Figure 3
Figure 3. Forest plot of ORs with 95% CI for XRCC1 Arg194Trp polymorphism and the risk of PTC under dominant model.
The center of each square represents the OR, the area of the square is the number of sample and thus the weight used in the meta-analysis, and the horizontal line indicates the 95%CI.
Figure 4
Figure 4. Begg's funnel plots of Arg399Gln polymorphism and the risk of DTC for publication bias test.
Each point represents a separate study for the indicated association. Log (OR), natural logarithm of OR. Horizontal line, mean effect size. (A) Recessive model. (B) Dominant model.
See this image and copyright information in PMC

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Grants and funding

This work was supported by the National Natural Science Foundation of China (81170728, 81100584, 30901540, 81270038, 81201565), the Natural Science Foundation of Guangdong Province, China (S2011040003050, S2012010009404), the Foundation for Distinguished Young Talents in Higher Education of Guangdong, China (LYM11038), the Specialized Research Fund for the Doctoral Program of Higher Education of China (20124433120001), the Medical Scientific Research Foundation of Guangdong Province, China (B2012202) and the Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China (2013029). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.