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. 2013 Apr;19(4):652-4.
doi: 10.3201/eid1904.121295.

Genetic relatedness of dengue viruses in Key West, Florida, USA, 2009-2010

Jorge L Muñoz-Jordán  1 , Gilberto A Santiago, Harold Margolis, Lillian Stark
Affiliations

Genetic relatedness of dengue viruses in Key West, Florida, USA, 2009-2010

Jorge L Muñoz-Jordán et al. Emerg Infect Dis. 2013 Apr.

Abstract

Sequencing of dengue virus type 1 (DENV-1) strains isolated in Key West/Monroe County, Florida, indicate endemic transmission for >2 years of a distinct and predominant sublineage of the American-African genotype. DENV-1 strains isolated elsewhere in Florida grouped within a separate Central American lineage. Findings indicate endemic transmission of DENV into the continental United States.

Keywords: DENV-1; Florida; Key West; dengue virus; phylogeny; vector-borne infections; viruses.

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Figures

Figure 1
Figure 1
Maximum-likelihood phylogenetic tree of dengue virus type 1, including isolates from Key West, Florida, USA, and representative isolates from 5 genotypes with global geographic distribution. Solid circles, 8 Key West viruses (Monroe County) isolated during 2009–2010; solid diamonds, isolates from other Florida counties (Dade, Pinellas, Orange, and Broward Counties). Scale bar indicates nucleotide substitutions per site. Each taxon represents a single virus isolate and is labeled with the geographic origin and collection year. All Florida viruses were labeled with the county of origin. Boldface taxa labels indicate the Key West lineage and cases not associated with travel. Isolate KW-Monroe/2009/JQ425068 represents the 2009 Key West outbreak index case virus. Thirty-six envelope glycoprotein gene sequences obtained from GenBank were included to support tree topology and identify genotypes. All genotypes except the American–African genotype (V) have been collapsed. Taxa labels and GenBank accession numbers are available in Technical Appendix.
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