Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr 30;13(1):37.
doi: 10.1186/1475-2867-13-37.

Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML

Li Shi  1 , Shaohua Chen, Yuhong Lu, Xu Wang, Ling Xu, Fan Zhang, Lijian Yang, Xiuli Wu, Bo Li, Yangqiu Li
Affiliations

Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML

Li Shi et al. Cancer Cell Int. .

Abstract

To elucidate the characteristics of T-cell receptor (TCR) signal transduction in T-cells from acute myeloid leukemia (AML), the mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), A20, NF-κB and MALT1-V1 gene expression levels in CD3+ T cells sorted from the peripheral blood of patients with AML were analyzed by real-time PCR. A significantly lower MALT1 and A20 expression level was found in T cells from patients with AML compared with healthy controls (p = 0.045, p < 0.0001); however, the expression level of MALT1-V1 (variant 1) was significantly higher in the AML group than in the healthy control group (p = 0.006), and the expression level of NF-κB was increased in the AML group. In conclusion, the characteristics of the expression pattern of MALT1-A20-NF-κB and the distribution of MALT1 variants in T cells from AML were first characterized. Overall, low TCR-CD3 signaling is related to low MALT1 expression, which may related to T cell immunodeficiency, while the up-regulation of MALT1-V1 may play a role in overcoming the T cell activity by downregulating A20 in patients with AML, which may be related to a specific response to AML-associated antigens.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic diagram of signal transduction of MALT1-A20-NF-κB in T cells from patients with AML.
Figure 2
Figure 2
The relative expression level of the MALT1 (A), A20 (B), and NF-κB (C) genes in the healthy control and AML groups.
Figure 3
Figure 3
The relative expression level (A) and ratio (B) of the MALT1-V1 gene in the healthy control and AML groups.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Takahashi S. Current findings for recurring mutations in acute myeloid leukemia. J Hematol Oncol. 2011;4:36. doi: 10.1186/1756-8722-4-36. - DOI - PMC - PubMed
    1. Schläfli AM, Torbett BE, Fey MF, Tschan MP. BIRC6 (APOLLON) is down-regulated in acute myeloid leukemia and its knockdown attenuates neutrophil differentiation. Exp Hematol Oncol. 2012;1(1):25. doi: 10.1186/2162-3619-1-25. - DOI - PMC - PubMed
    1. Lin C, Li Y. The role of peptide and DNA vaccines in myeloid leukemia immunotherapy. Cancer Cell Int. 2013;13(1):13. doi: 10.1186/1475-2867-13-13. - DOI - PMC - PubMed
    1. Chen S, Zha X, Yang L, Li B, Liye Z, Li Y. Deficiency of CD3gamma, delta, epsilon, and zeta expression in T cells from AML patient. Hematology. 2011;16(1):31–36. doi: 10.1179/102453311X12902908411832. - DOI - PubMed
    1. Li Y, Geng S, Yin Q, Chen S, Yang L, Wu X, Li B, Du X, Schmidt CA, Przybylski GK. Decreased level of recent thymic emigrants in CD4+ and CD8 + T cells from CML patients. J Transl Med. 2010;8:47. doi: 10.1186/1479-5876-8-47. - DOI - PMC - PubMed

LinkOut - more resources