Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor
- PMID: 23611952
- DOI: 10.1016/j.addr.2013.04.011
Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor
Abstract
Multidrug resistance (MDR) is a major obstacle to successful cancer therapy, especially for chemotherapy. The new drug delivery system (DDS) provides promising approaches to reverse MDR, for which the poor cellular uptake and insufficient intracellular drug release remain rate-limiting steps for reaching the drug concentration level within the therapeutic window. Stimulus-coupled drug delivery can control the drug-releasing pattern temporally and spatially, and improve the accumulation of chemotherapeutic agents at targeting sites. In this review, the applications of DDS which is responsive to different types of stimuli in MDR cancer therapy is introduced, and the design, construction, stimuli-sensitivity and the effect to reverse MDR of the stimuli-responsive DDS are discussed.
Keywords: Chemotherapy; Drug delivery; Multidrug resistance; Responsive; Stimuli; Tumor.
Copyright © 2013 Elsevier B.V. All rights reserved.
Similar articles
-
Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system.Arch Pharm Res. 2014 Jan;37(1):4-15. doi: 10.1007/s12272-013-0276-2. Epub 2013 Nov 23. Arch Pharm Res. 2014. PMID: 24272889 Review.
-
Role of integrated cancer nanomedicine in overcoming drug resistance.Adv Drug Deliv Rev. 2013 Nov;65(13-14):1784-802. doi: 10.1016/j.addr.2013.07.012. Epub 2013 Jul 21. Adv Drug Deliv Rev. 2013. PMID: 23880506 Review.
-
Nanodrug delivery systems for targeting the endogenous tumor microenvironment and simultaneously overcoming multidrug resistance properties.J Control Release. 2017 Apr 10;251:49-67. doi: 10.1016/j.jconrel.2017.02.020. Epub 2017 Feb 21. J Control Release. 2017. PMID: 28232226 Review.
-
Classification of stimuli-responsive polymers as anticancer drug delivery systems.Drug Deliv. 2015 Feb;22(2):145-55. doi: 10.3109/10717544.2014.887157. Epub 2014 Feb 19. Drug Deliv. 2015. PMID: 24547737 Review.
-
Nanoparticle approaches to combating drug resistance.Future Med Chem. 2015 Aug;7(12):1503-10. doi: 10.4155/fmc.15.82. Epub 2015 Aug 27. Future Med Chem. 2015. PMID: 26334205 Review.
Cited by
-
Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy.Nano Lett. 2016 Sep 14;16(9):5401-8. doi: 10.1021/acs.nanolett.6b01632. Epub 2016 Aug 8. Nano Lett. 2016. PMID: 27490088 Free PMC article.
-
Chitosan Nanoparticle-Based System: A New Insight into the Promising Controlled Release System for Lung Cancer Treatment.Molecules. 2022 Jan 12;27(2):473. doi: 10.3390/molecules27020473. Molecules. 2022. PMID: 35056788 Free PMC article. Review.
-
Sericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse cancer drug resistance.Drug Deliv. 2018 Nov;25(1):1103-1116. doi: 10.1080/10717544.2018.1469686. Drug Deliv. 2018. PMID: 29742945 Free PMC article.
-
Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphoma.Sci Rep. 2017 Feb 15;7:42632. doi: 10.1038/srep42632. Sci Rep. 2017. PMID: 28198453 Free PMC article.
-
Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting.Cancers (Basel). 2021 Feb 7;13(4):670. doi: 10.3390/cancers13040670. Cancers (Basel). 2021. PMID: 33562376 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
