Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
- PMID: 23580138
- PMCID: PMC3627038
- DOI: 10.1007/s10577-013-9347-y
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
Abstract
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
Comment in
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Phylogeny as the basis for naming histones.Trends Genet. 2013 Sep;29(9):499-500. doi: 10.1016/j.tig.2013.06.009. Epub 2013 Jul 19. Trends Genet. 2013. PMID: 23876620 No abstract available.
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CENP-A and the CENP nomenclature: response to Talbert and Henikoff.Trends Genet. 2013 Sep;29(9):500-2. doi: 10.1016/j.tig.2013.06.008. Epub 2013 Aug 2. Trends Genet. 2013. PMID: 23910159 No abstract available.
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